The psychology of psychiatric genetics: evidence that positive emotions in females moderate genetic sensitivity to social stress associated with the BDNF Val-sup-6-sup-6Met polymorphism

Journal of Abnormal Psychology
M WichersJ van Os

Abstract

Previous work indicated protective effects of positive emotions on genetically influenced stress sensitivity. Given the fact that expression of brain-derived-neurotrophic-factor (BDNF) is associated with stress-induced behavioral changes, it was hypothesized that the BDNF Val-sup-6-sup-6Met genotype may mediate genetic effects on stress sensitivity, conditional on the level of concurrent positive emotions. Subjects (n=446) participated in a momentary assessment study, collecting appraisals of stress and affect in the flow of daily life. Multilevel regression analyses examined moderation of daily life stress-induced negative affect (NA) by BDNF genotype, and to what degree this was conditional on concurrent positive emotions. Results showed that heterozygous BDNF "Met" carriers exhibited an increased NA response to social stress compared with "Val/Val" subjects. Positive emotions at the time of the stressor decreased BDNF genetic moderation of the NA response to social stress in a dose-response fashion. This effect was most pronounced in BDNF Met carriers. Thus, the impact of BDNF genotype on stress sensitivity is conditional on the experience of positive emotions. Interdisciplinary research in psychology and psychiatric genetic...Continue Reading

Citations

Feb 14, 2009·Psychological Medicine·I Myin-GermeysJ van Os
Feb 3, 2010·Psychological Medicine·M WichersF Peeters
Jul 27, 2012·Translational Psychiatry·M L MolendijkB M Elzinga
Aug 30, 2008·Genes, Brain, and Behavior·C J P SimonsJ van Os
Mar 11, 2011·Psychoneuroendocrinology·Katie R KryskiElizabeth P Hayden
Aug 3, 2013·Brain Research Bulletin·Adrian M StankiewiczPawel Lisowski
Oct 16, 2014·Journal of Psychopharmacology·Roger M Lane
Apr 21, 2018·Critical Reviews in Clinical Laboratory Sciences·Robin N GroenAlbert K Groen
Jan 30, 2010·Depression and Anxiety·Benedikt KlaukeKatharina Domschke
Jan 13, 2010·Acta Psychiatrica Scandinavica·N GeschwindM Wichers
Aug 16, 2011·Acta Psychiatrica Scandinavica·M WichersJ van Os
May 15, 2012·Psychosomatic Medicine·Patrick H FinanMary C Davis
Apr 22, 2015·European Psychiatry : the Journal of the Association of European Psychiatrists·M van WinkelF Peeters
Mar 16, 2013·Acta Psychiatrica Scandinavica·B P F RuttenM Wichers
Jun 22, 2013·Developmental Science·Katie R KryskiElizabeth P Hayden
Feb 26, 2020·European Psychiatry : the Journal of the Association of European Psychiatrists·Paula Cristóbal-NarváezNeus Barrantes-Vidal
Jun 6, 2013·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Jim van OsMarieke Wichers
Sep 27, 2018·Journal of Abnormal Child Psychology·Kerstin StülbSimone Munsch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.