PMID: 7545337Jul 1, 1995Paper

The PTB domain: a new protein module implicated in signal transduction

Trends in Biochemical Sciences
P van der Geer, T Pawson

Abstract

Src homology 2 (SH2) domains have been identified in a large number of proteins involved in signal transduction downstream of receptor tyrosine kinases. They allow cytoplasmic signalling proteins to bind specifically to other polypeptides that are phosphorylated on tyrosine in response to growth factor stimulation. A novel phosphotyrosine-binding (PTB) domain has been identified recently in the amino terminus of Shc, an adaptor molecule that appears to be involved in Ras activation PTB domains are longer than SH2 domains, and recognize phosphotyrosine in the context of amino-terminal residues, in contrast to SH2 domains, which recognize them in the context of carboxy-terminal residues.

References

Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B MargolisJ Schlessinger
Oct 4, 1984·Nature·J DownwardM D Waterfield
Dec 16, 1994·Science·W M Kavanaugh, L T Williams
Feb 16, 1995·Nature·T Pawson
Mar 10, 1995·Cell·P Bork, B Margolis
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·K S CampbellD C Pallas
May 6, 1993·Nature·F McCormick

❮ Previous
Next ❯

Citations

Jan 7, 1998·Journal of Neuroscience Research·H H AlthausR Heumann
Sep 29, 1999·Journal of Cellular Biochemistry·Y Xu, G Carpenter
Oct 25, 2002·Diabetes/metabolism Research and Reviews·Silvia Mora, Jeffrey E Pessin
Mar 1, 1996·Protein Science : a Publication of the Protein Society·S RétyG Waksman
Jun 29, 2000·Biochemical and Biophysical Research Communications·M IsekiK Takatsu
Nov 22, 2001·Biochemical and Biophysical Research Communications·R HomayouniT Curran
Mar 11, 2008·Journal of Molecular Neuroscience : MN·Hans H AlthausMatthias Schmitz
Jan 1, 1996·Trends in Endocrinology and Metabolism : TEM·A P BevanB I Posner
Dec 5, 1998·Biochimica Et Biophysica Acta·M J BottomleyG Panayotou
Mar 26, 2002·FEBS Letters·Kelley S YanMing Ming Zhou
Jan 1, 1996·Progress in Biophysics and Molecular Biology·M Sudol
Jul 25, 2003·Brain Research. Molecular Brain Research·Ramin HomayouniTom Curran
Jul 20, 1999·Molecular and Cellular Endocrinology·I PirsonD Perez-Morga
Jul 11, 1998·Biochimica Et Biophysica Acta·M A FarrarK Sauer
Dec 1, 1996·Cellular Signalling·F Romero, S Fischer
Oct 6, 1997·Cellular Signalling·N Dunant, K Ballmer-Hofer
Sep 7, 2001·Current Opinion in Cell Biology·D R PhillipsL Nannizzi-Alaimo
Dec 23, 1999·Current Opinion in Structural Biology·J D Forman-Kay, T Pawson
Dec 1, 1995·Trends in Cell Biology·P C BaassJ J Bergeron
Oct 3, 1998·Trends in Biochemical Sciences·M J Wishart, J E Dixon
Jun 19, 2002·Trends in Cardiovascular Medicine·Peter van der Geer
Mar 1, 1997·The International Journal of Biochemistry & Cell Biology·J J Hsuan, S H Tan
Aug 8, 1998·Breast Cancer Research and Treatment·L E Stevenson, A R Frackelton
Feb 14, 2002·British Journal of Haematology·Liping Geng, Christopher E Rudd
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·K S RavichandranS J Burakoff
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·X Y LiuJ Hawiger
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·P van der GeerT Pawson
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·J E DamenG Krystal
Jan 29, 2002·The Journal of Biological Chemistry·Karen K Cook, Debra A Fadool
Aug 1, 1997·Molecular Biology of the Cell·J H WrightE G Krebs
May 25, 1999·Inflammatory Bowel Diseases·N J Boerth, G A Koretzky

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.