The PTH-calcium relationship during a range of infused PTH doses in the parathyroidectomized rat

Calcified Tissue International
I BerdudArnold J Felsenfeld

Abstract

To establish the PTH dosage that maintains normal mineral homeostasis in the PTX rat, a series of doses of rat 1-34 PTH were infused via a subcutaneously implanted miniosmotic pump. The doses were 0, 0.011, 0.022, 0.044, and 0.11 microg/100 g/hour. After 48 hours, serum calcium ranged from 5.56 +/- 0.02 to 16.29 +/- 0.25 mg/dl, ANOVA P < 0.001, and serum phosphorus from 12.49 +/- 0.03 to 5.33 +/- 0.34 mg/dl, ANOVA P < 0.001. By post hoc test, the serum calcium level was different (P < 0.05) at every PTH dose; the serum phosphorus level was different (P < 0.05) at every PTH dose except between the two highest doses. The PTH dosage that produced a normal serum calcium (10.09 +/- 0.10 mg/dl) and phosphorus (6.90 +/- 0.18 mg/dl) was 0.022 microg/100 g/hour. The relationship between increasing doses of PTH and both serum calcium and phosphorus was curvilinear and the calcium-phosphorus product was remarkably constant from a serum calcium of 7-13 mg/dl. The increase in serum calcium and the decrease in serum phosphorus were more rapid at lower than at higher PTH doses so that for both, an asymptote was reached. At the highest serum calcium values, the calcium-phosphorus product increased and in individual rats, an increase in serum p...Continue Reading

Citations

May 7, 1999·European Journal of Clinical Investigation·A J Felsenfeld
Jun 30, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yoshiko Iwasaki-IshizukaMasafumi Fukagawa
Jan 28, 2004·Bioscience, Biotechnology, and Biochemistry·Shin-Ichi KatsumataKazuharu Suzuki
Apr 6, 2007·Kidney International·K R NevesR M A Moysés
Apr 29, 2011·Kidney International·Ignacio LópezEscolástico Aguilera-Tejero
Jan 25, 2011·Translational Research : the Journal of Laboratory and Clinical Medicine·Maya Otto-DuesselJohn C Wood
Jan 5, 2005·BioFactors·Shin-ichi KatsumataKazuharu Suzuki
Dec 19, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ruiye BiMichael Mannstadt
Oct 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Arnold J FelsenfeldEscolástico Aguilera-Tejero
Nov 20, 2003·American Journal of Physiology. Renal Physiology·Weidong WangSøren Nielsen
Mar 16, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Laura Martínez-AriasManuel Naves-Díaz
Apr 15, 1999·Journal of the American Society of Nephrology : JASN·A J Felsenfeld, M Rodriguez

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