The PTPN13 Y2081D (T>G) (rs989902) polymorphism is associated with an increased risk of sporadic colorectal cancer

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
I LaczmanskaM M Sasiadek

Abstract

Colorectal cancer (CRC) is one of the most common cancers worldwide and, although the majority of cases are sporadic, its development and progression depends on a range of factors: environmental, genetic and epigenetic. A variety of genetic pathways have been described as being crucial in CRC, including protein tyrosine phosphatases (PTPs). PTPN13 (also called FAP-1) is a non-receptor PTP and interacts with a number of important components of growth and apoptosis pathways. It is also involved in the inhibition of Fas-induced apoptosis. The single nucleotide polymorphism genotype at Y2081D (T>G) (rs989902) of PTPN13 exon 39 was determined in DNA extracted from blood samples from 174 sporadic CRC patients and 176 healthy individuals. Also, a meta-analysis was performed based on three articles accessed via the PubMed and ResearchGate databases. The risk of CRC was 2.087 times greater for patients with the GG genotype than for those with the TT genotype (P = 0.0475). In the meta-analysis, a significantly increased risk of cancer associated with the G allele was observed in the squamous cell carcinoma of the head and neck subgroup (TT vs GG+GT, OR 1.23, 95% CI [1.02, 1.47], P = 0.0258), and a significantly decreased risk in the brea...Continue Reading

References

Feb 19, 2004·British Journal of Cancer·H C Erichsen, S J Chanock
May 25, 2004·Science·Zhenghe WangVictor E Velculescu
Aug 13, 2009·Journal of Cancer Research and Clinical Oncology·Yuichiro MitaKenji Shimizu
Dec 24, 2010·Nature Reviews. Cancer·Sofi G JulienMichel L Tremblay
Jun 29, 2011·Anti-cancer Agents in Medicinal Chemistry·Serge HardyMichel L Tremblay
Oct 19, 2011·Molecular Carcinogenesis·Pawel KarpinskiMaria M Sasiadek
Jan 17, 2012·The American Journal of Pathology·Marianna ScrimaGiuseppe Viglietto
Aug 3, 2013·Experimental and Molecular Pathology·Xiujuan HanWei Zhang
Dec 18, 2013·Genetics and Molecular Research : GMR·W WeiW Q Dong
May 2, 2014·World Journal of Gastroenterology : WJG·Juwon KimKyung-A Lee
Sep 16, 2014·Acta Pharmacologica Sinica·Rong-Jun HeZhong-Yin Zhang
Jan 24, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hao ZhanXiaowu Huang

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Citations

Dec 29, 2020·Frontiers in Cell and Developmental Biology·Shuo WangJianming Lu
Dec 17, 2020·Biomolecules·Soha McheikGilles Freiss

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