The PTPN22 R263Q polymorphism confers protection against systemic lupus erythematosus and rheumatoid arthritis, while PTPN22 R620W confers susceptibility to Graves' disease in a Mexican population

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Daniela Josabeth López-CanoJ Ramírez Bello

Abstract

The functional PTPN22 R620W polymorphism (rs2476601) is clearly associated with susceptibility to several autoimmune diseases (ADs). However, the PTPN22 R263Q polymorphism (rs33996649) has been scarcely explored in different ADs. Here we aimed to examine the associations of the PTPN22 R620W and R263Q polymorphisms with susceptibility to or protection against rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Graves' disease (GD) among Mexican patients. We conducted a case-control study including 876 patients (405 with SLE, 388 with RA, and 83 with GD) and 336 healthy control individuals. PTPN22 genotypes were determined using the TaqMan 5' allele discrimination assay. PTPN22 R620W was associated with GD susceptibility (OR 4.3, p = 0.004), but was not associated with SLE (OR 1.8, p = 0.19). We previously demonstrated that this polymorphism is associated with RA susceptibility (OR 4.17, p = 0.00036). Moreover, PTPN22 R263Q was associated with protection against SLE (OR 0.09, p = 004) and RA (OR 0.28, p = 0.045), but was not associated with GD. Our data provide the first demonstration that PTPN22 R620W confers GD susceptibility among Latin-American patients. Moreover, this is the second report documenting the assoc...Continue Reading

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Citations

Feb 7, 2018·Molecular Biology Reports·Daniel Cadena-SandovalJulián Ramírez-Bello
Sep 27, 2018·Expert Opinion on Therapeutic Targets·F David Carmona, Javier Martín
Mar 19, 2019·International Journal of Immunogenetics·Sara Cristina Lobo-AlvesMaria Luiza Petzl-Erler
May 28, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Julian Ramírez-BelloFausto Sánchez-Muñoz
Nov 25, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·María Elena SotoJulian Ramírez-Bello
Nov 30, 2018·Physiological Research·D VejrazkovaB Bendlova
Jan 12, 2021·Frontiers in Cell and Developmental Biology·Patricia Castro-SanchezRose Zamoyska

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

Rad CFX Manager
FINETTI
Epidat
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