The public health imperative for a neonatal herpes simplex virus infection surveillance system

Sexually Transmitted Diseases
Betty A DonovalJeffrey D Klausner

Abstract

About 1 in 5 sexually active adults in the United States has serologic evidence of genital herpes caused by herpes simplex virus type-2. Neonatal herpes simplex virus infection is a serious consequence of genital herpes infection. Herpes infection in neonates causes significant morbidity and neurologic damage and generally has a case-fatality ratio untreated of 60%. It is estimated that 440 to 1,320 cases of neonatal herpes infections occur in the United States per year (11-33 cases occur per 100,000 live births). Given the challenges in surveillance for genital herpes due to the large number of asymptomatic infections and infrequent laboratory-based diagnosis, we recommend that to begin an effective national control program for herpes infections, a mandatory national surveillance system for neonatal herpes be implemented. Such a system would help assure appropriate therapy, help monitor trends and understand the burden of disease, identify risk determinants, and evaluate prevention efforts.

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Citations

Jul 21, 2009·Sexually Transmitted Diseases·Lilliam AmbroggioSamir S Shah
Jan 16, 2013·Clinical & Developmental Immunology·Aziz Alami Chentoufi, Lbachir Benmohamed
May 1, 2007·American Journal of Obstetrics and Gynecology·Nichole MahnertGeorge D Wendel
Aug 17, 2011·Sexually Transmitted Diseases·Shoshanna HandelJulia A Schillinger
Jan 2, 2007·Current Opinion in Infectious Diseases·David A Baker
Dec 25, 2007·Sexually Transmitted Diseases·Thu-Ha DinhStuart Berman
Dec 25, 2007·Sexually Transmitted Diseases·Carolyn GardellaRichard Whitley
Sep 1, 2007·Women's Health·Anne Buvé
Oct 22, 2013·The Pediatric Infectious Disease Journal·Joseph B Cantey, Pablo J Sánchez
Mar 28, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·Jung S HwangKenneth M Zangwill

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