PMID: 6398050Oct 1, 1984Paper

The pulmonary alveolar macrophage

Australian and New Zealand Journal of Medicine
G McLennan, N DeYoung

Abstract

The pulmonary alveolar macrophage (PAM) occupies a unique environment, with exposure to both the atmosphere and the blood stream. This position enables the PAM to perform its primary role of protecting the lung from inhaled, potentially damaging, agents. The effects of long term cigarette smoking on the human PAM appear to be functionally minimal when the cells are studied as a group, but the marked recruitment of PAM's which occurs in smokers leads to a greater potential for PAM helpful and/or damaging activity within the lung. The traditional role of phagocytosis is not a global function of the unstimulated human PAM. Of increasing importance for the understanding of pulmonary disease is the ability of the PAM to modulate lymphocyte, polymorphonuclear leukocyte and fibroblast activity. These functions are primarily for the defence of the lung but often produce temporary or permanent lung damage. Subclassification of the human PAM based upon functional heterogeneity may lead to a better understanding of the role of this cell.

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Citations

Jan 1, 1988·Lung·F K KesslerR A Carchman
Jan 1, 1990·Molecular Aspects of Medicine·A Shock, G J Laurent
Nov 24, 2006·American Journal of Respiratory Cell and Molecular Biology·Kate E MatthewsFranca Ronchese
Jul 21, 2007·American Journal of Respiratory Cell and Molecular Biology·Celine A Beamer, Andrij Holian

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