The pulmonary vasoconstrictor response to hypoxia: effects of inhibitors of prostaglandin biosynthesis.

Acta Physiologica Scandinavica
J VaageA Hauge

Abstract

The main purpose of the present work was to determine whether prostaglandins (PGs) synthetised in the lungs mediate the vasoconstrictor response to acute alveolar hypoxia. Isolated and ventilated lungs of rats were perfused at 37 degrees C with homologous blood at constant-volume, pulsatile inflow, and pressor responses to 3 min periods of standardized ventilation hypoxia recorded. Indomethacin, sodium meclofenamate and acetylsalicylic acid (all 100 mug/ml), which are potent inhibitors of PG biosynthesis, did not reduce the hypoxic vasoconstrictor response. Sometimes they even enhanced this response. We conclude that PGs do not mediate the hypoxia-induced vasoconstriction. We suggest that vasodilatory PGs might act to reduce and modify pulmonary arterial hypertension due to hypoxia.

References

Apr 30, 1971·Annals of the New York Academy of Sciences·P Piper, J Vane
Dec 1, 1972·The Journal of Clinical Investigation·F Haas, E H Bergofsky
Jan 1, 1974·The American Journal of Physiology·J M KayR F Grover
Jun 1, 1969·Journal of Applied Physiology·A Hauge, N C Staub
Oct 1, 1974·Physiological Reviews·Y S Bakhle, J R Vane
Dec 1, 1973·Journal of Applied Physiology·E D Silove, A J Simcha
Oct 1, 1971·Journal of Applied Physiology·A Susmano, R A Carleton
Mar 1, 1971·The British Journal of Surgery·E M BerryH Wyllie
May 1, 1963·Acta Physiologica Scandinavica·E ANGGARD, S BERGSTROM

❮ Previous
Next ❯

Citations

Aug 1, 1979·The Journal of Clinical Investigation·M A Miller, C A Hales
Sep 1, 1996·Avian Pathology : Journal of the W.V.P.A·A ShlosbergE Berman
Apr 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D JohnsonT Hurst
Mar 1, 1976·International Journal of Biometeorology·F L Hays, W Bianca
Nov 1, 2003·Thrombosis Research·Randy S SpragueAndrew J Lonigro
Jan 1, 1989·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·Y C Su, X R Jin
Feb 1, 1978·Acta Physiologica Scandinavica·T WibergK M Gautvik
Apr 1, 1977·Respiration Physiology·C A HalesH Kazemi
Jan 1, 1991·Acta Anaesthesiologica Scandinavica. Supplementum·A Jolin, L Bjertnaes
Apr 1, 1982·Prostaglandins, Leukotrienes, and Medicine·Y HamasakiS I Said
Dec 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D L KongW D Watkins
Nov 1, 1984·Clinical and Experimental Pharmacology & Physiology·A D Siefkin, G H Parsons
Jun 26, 2007·The Annals of Thoracic Surgery·Oliver J LiakopoulosHilmar Dörge
Oct 1, 1981·Scandinavian Journal of Clinical and Laboratory Investigation·G FrimanL Pilström
Sep 1, 1979·Circulation Research·A L Hyman, P J Kadowitz
Jan 1, 1982·Annals of the New York Academy of Sciences·R H Demling
Feb 1, 1976·Acta Physiologica Scandinavica·L J BjertnaesJ E Bredesen
Feb 3, 2012·Physiological Reviews·J T SylvesterJeremy P T Ward

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.