The pumpless extracorporeal lung membrane provides complete respiratory support during complex airway reconstructions without inducing cellular trauma or a coagulatory and inflammatory response

The Journal of Thoracic and Cardiovascular Surgery
David Sanchez-LorentePaolo Macchiarini

Abstract

Our objective was to investigate the capacity of a pumpless extracorporeal lung membrane (iLA) (Novalung; Novalung GmbH, Hechingen, Germany) to provide adequate respiratory support and the impact on morbidity/mortality during complex airway reconstruction. Only patients unable to be ventilated via conventional intubation were eligible for the study. A larynx mask or orotracheal tubes were placed above the airway defect and the iLA was attached via femoral vessels (arteriovenous), providing extracorporeal gas exchange, apneic hyperoxygenation, and total tubeless airway reconstruction. Haptoglobulin, plasmin-antiplasmin complex, P-selectin activation, and interleukin 6 were measured before, during, and after iLA use and 72 hours postoperatively. Fifteen consecutive patients (age, 42±17 years) underwent elective (n=7) or emergency (n=8) reconstruction of the airway owing to a variety of disorders or defects. The iLA was left in place for 185±61 minutes, diverted 1.70±0.48 L/min of the cardiac output, and provided an arteriovenous carbon dioxide removal and oxygen transfer of 173±94 and 144±83 mL/min, respectively. The arterial oxygen tension/inspired oxygen fraction (314±31 mm Hg), and arterial carbon dioxide tension (40±6 mm Hg) ...Continue Reading

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Citations

Dec 1, 2012·Current Opinion in Anaesthesiology·Philip E F RomanAlina M Grigore
Apr 12, 2014·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Alexander HermannPeter Schellongowski
Dec 4, 2013·Thoracic Surgery Clinics·Klaus Wiedemann, Clemens Männle
Dec 3, 2014·Journal of Cardiothoracic and Vascular Anesthesia·Fulvio PinelliPaolo Macchiarini
Oct 28, 2017·Khirurgiia·D V BazarovA A Volkov
Aug 20, 2020·The Thoracic and Cardiovascular Surgeon·Lorenzo SpaggiariFrancesco Alamanni
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Jun 3, 2021·Membranes·Pavel SukIvan Čundrle
Jun 18, 2021·Prague Medical Report·Michal PořízkaBasem B Abdelmalak

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