The purine 2-amino group as a critical recognition element for binding of small molecules to DNA

Gene
M J Waring, C Bailly

Abstract

The expedient of preparing homologous DNA samples substituted with I for G, DAP for A, or both, has been used to investigate the role of the purine 2-amino group in determining the preferred binding sites for antibiotics on DNA. The selectivity of echinomycin for CpG steps, of actinomycin for GpC steps, and of netropsin for A + T-rich tracts, is seen to be radically altered in the substituted DNA molecules.

References

Feb 4, 1992·Biochemistry·J Goodisman, J C Dabrowiak
Apr 1, 1990·Computer Applications in the Biosciences : CABIOS·J M Smith, D J Thomas
May 1, 1989·Quarterly Reviews of Biophysics·X L Gao, D J Patel
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D E GilbertJ Feigon
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M L KopkaR E Dickerson
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L A Marky, K J Breslauer
Sep 1, 1987·European Journal of Biochemistry·J Portugal, M J Waring
Sep 14, 1984·Science·M M Van Dyke, P B Dervan
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M J LaneJ N Vournakis
Jun 1, 1984·Cell·H R Drew, A A Travers
Mar 16, 1993·Biochemistry·C BaillyM J Waring

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Citations

Dec 31, 2003·International Journal of Pharmaceutics·Masaki TokunagaToshihisa Yotsuyanagi
Feb 16, 2000·Journal of Neuroimmunology·K KajiwaraK J Wood
Oct 6, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·M KurisawaT Okano
Mar 20, 2002·European Journal of Medicinal Chemistry·Luis Chacón-García, Roberto Martínez
Jun 6, 2003·Cancer Treatment Reviews·Joseph M KaminskiBoris Minev
Dec 29, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G Mathé
Oct 1, 1996·Current Opinion in Neurobiology·R S Slack, F D Miller
Jul 17, 1998·Current Opinion in Structural Biology·J B Chaires
Dec 7, 2013·Journal of Chemical Information and Modeling·Yocheved Gilad, Hanoch Senderowitz
Sep 8, 2011·The Journal of Physical Chemistry. a·Yevgeniy NosenkoBernhard Brutschy
Apr 1, 1997·British Journal of Urology·K Sikora, H Pandha
Jun 29, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Alessio TerenziMichael J Hannon
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Mohammad Hasanzadeh, Nasrin Shadjou
May 8, 2013·Journal of Photochemistry and Photobiology. B, Biology·Muhammad SirajuddinAmin Badshah
Mar 10, 2009·Journal of Molecular Graphics & Modelling·Marco A Loza-MejíaAlfonso Lira-Rocha
Nov 3, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Anup PaulArmando J L Pombeiro
Dec 21, 2012·Current Protocols in Nucleic Acid Chemistry·Rupesh Nanjunda, W David Wilson
Jun 1, 1995·European Journal of Biochemistry·C AlhambraM Orozco
Feb 10, 1998·Biochemistry·C BaillyJ B Chaires
Nov 18, 2004·Bioconjugate Chemistry·Zhanna V ZhilinaScot W Ebbinghaus

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