Cardiac Purkinje fibers, due to their unique anatomical location, cell structure and electrophysiologic characteristics, play an important role in cardiac conduction and arrhythmogenesis. Purkinje cell action potentials are longer than their ventricular counterpart, and display two levels of resting potential. Purkinje cells provide for rapid propagation of the cardiac impulse to ventricular cells and have pacemaker and triggered activity, which differs from ventricular cells. Additionally, a unique intracellular Ca2+ release coordination has been revealed recently for the normal Purkinje cell. However, since the isolation of single Purkinje cells is difficult, particularly in small animals, research using Purkinje cells has been restricted. This review concentrates on comparison of Purkinje and ventricular cells in the morphology of the action potential, ionic channel function and molecular determinants by summarizing our present day knowledge of Purkinje cells.
The kinetics of the inhibition by dihydroouabain of the sodium pump current in single rabbit cardiac Purkinje cells
Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel
Electrogenic Na(+)-K+ pump in Purkinje myocytes isolated from control noninfarcted and infarcted hearts
Differences in the electrophysiological response of canine ventricular subendocardium and subepicardium to acetylcholine and isoproterenol. A direct effect of acetylcholine in ventricular myocardium
Does if control normal automatic rate in canine cardiac Purkinje fibers? Studies on the negative chronotropic effects of lidoflazine
Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells
Electrophysiology and ultrastructure of canine subendocardial Purkinje cells isolated from control and 24-hour infarcted hearts
Circus movement in the canine atrium around the tricuspid ring during experimental atrial flutter and during reentry in vitro
Acceleration of ventricular pacemakers by transient increases in heart rate in dogs during ouabain administration
An analysis of the rate-dependent action of lidoflazine in mammalian sino-atrial node and Purkinje fibres
Single cardiac Purkinje cells: general electrophysiology and voltage-clamp analysis of the pace-maker current
Effects of extracellular potassium accumulation and sodium pump activation on automatic canine Purkinje fibres
A study of the effect of the rate of stimulation on the transient outward current in sheep cardiac Purkinje fibres
Regulation of adenosine triphosphate-sensitive potassium channels from rabbit ventricular myocytes by protein kinase C and type 2A protein phosphatase
Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization
Modulation of the electrical restitution of canine Purkinje fibers by local anesthetic drugs: a study with flecainide and propafenone
Immunohistochemical delineation of the conduction system. II: The atrioventricular node and Purkinje fibers
Dissociated spatial patterning of gap junctions and cell adhesion junctions during postnatal differentiation of ventricular myocardium
Effects of the diuretic agent indapamide on Na+, transient outward, and delayed rectifier currents in canine atrial myocytes
Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues
The role of the delayed rectifier component IKs in dog ventricular muscle and Purkinje fibre repolarization
Identification and properties of ATP-sensitive potassium channels in myocytes from rabbit Purkinje fibres
Calcium-activated Cl(-) current contributes to delayed afterdepolarizations in single Purkinje and ventricular myocytes
Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts
Analysis of the electrophysiological effects of ambasilide, a new antiarrhythmic agent, in canine isolated ventricular muscle and purkinje fibers
Impaired conduction in the bundle branches of mouse hearts lacking the gap junction protein connexin40
Modeling tissue- and mutation- specific electrophysiological effects in the long QT syndrome: role of the Purkinje fiber
The infrahisian conduction system and endocavitary cardiac structures: relevance for the invasive electrophysiologist
Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues
Peristalsis in the junction region of the Drosophila larval midgut is modulated by DH31 expressing enteroendocrine cells.
A model of canine purkinje cell electrophysiology and Ca(2+) cycling: rate dependence, triggered activity, and comparison to ventricular myocytes.
Role of the transient outward potassium current in the genesis of early afterdepolarizations in cardiac cells.
A computational model of Purkinje fibre single cell electrophysiology: implications for the long QT syndrome.
Ion channel subunit expression changes in cardiac Purkinje fibers: a potential role in conduction abnormalities associated with congestive heart failure
Transmural differences in myocardial contraction in long-QT syndrome: mechanical consequences of ion channel dysfunction
Isolated conduction within the left His-Purkenje system during sinus rhythm and idiopathic left ventricle tachycardia: findings from mapping the whole conduction system
Prevention of ventricular fibrillation through de-networking of the Purkinje system: Proof-of-Concept Paper on the Substrate Modification of the Purkinje Network
Role of the Purkinje-Muscle Junction on the Ventricular Repolarization Heterogeneity in the Healthy and Ischemic Ovine Ventricular Myocardium
Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior.
Bioengineering the Cardiac Conduction System: Advances in Cellular, Gene, and Tissue Engineering for Heart Rhythm Regeneration.
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Cardiac Conduction System
The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.