PMID: 7516051Feb 1, 1994Paper

The Purkinje cell in olivopontocerebellar atrophy. A Golgi and immunocytochemical study

Neuropathology and Applied Neurobiology
I FerrerT Serrano

Abstract

Purkinje cells were examined in three familial cases of olivopontocerebellar atrophy (OPCA) by means of the Golgi method, and neurofilament and calcium-binding protein immunocytochemistry. Reduced dendritic arborizations, as seen with different techniques, early formation of axonal spheroids, and abnormal accumulation of phosphorylated neurofilament epitopes in dendrites, somata and axonal spheroids, together with limited formation of proximal spine-like protrusions were the main changes in Purkinje cells. These lesions are unlikely to be the consequence of anterograde degeneration secondary to olivary atrophy, as postulated by some investigators, but probably represent primary damage to Purkinje cells in patients with OPCA. Reduced dendritic arborizations result in a decrease of receptor sites for parallel fibres and deprive granule cells of their main targets. Abnormal accumulation of neurofilaments in somata, dendrites and axonal spheroids may contribute to an abnormal transport and may impair protein turnover in the distal regions of Purkinje cells.

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Citations

Apr 19, 2006·Journal of Neurology·L Ramio-TorrentiaD Genis
Nov 24, 2001·Brain Research Bulletin·F R FuscoM Molinari
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