The PurR mutation of Drosophila melanogaster confers resistance to purine and 2,6-diaminopurine by elevating adenosine deaminase activity

Molecular & General Genetics : MGG
F L Dutton, A Chovnick

Abstract

Media supplemented with purine (7H-imidazo[4,5-d]pyrimidine) or the purine analogue 2,6-diaminopurine (DAP) can be employed to select several classes of purine-resistant variants from mutagenized cultures of Drosophila. One class results in elevated resistance to purine and diaminopurine which is correlated with elevated activity of the enzyme adenosine deaminase (adenosine aminohydrolase = EC 3.5.4.4). The first member of this class, Pur R, maps to position 82 +/- in the right arm of the second chromosome. The Pur R mutation causes an elevation of adenosine deaminase (ADA) enzyme activity, apparently by altering a thermolabile, ADA-specific repressor. Pur R may thus encode a negative regulator of adenosine deaminase activity similar to the ADA-binding protein found in mammalian systems.

References

Apr 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·V G FinnertyA Chovnick
Dec 19, 1967·Biochimica Et Biophysica Acta·L D Hodge, E Glassman
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D H Johnson, T B Friedman
Feb 8, 1980·Molecular and Cellular Biochemistry·P E Daddona, W N Kelley

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Citations

Apr 5, 2005·Insect Biochemistry and Molecular Biology·Eva DolezelovaPeter J Bryant

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