The puzzle of ploidy of Purkinje neurons

The Cerebellum
Ugo Del Monte

Abstract

This paper places attention on the discrepancies existing in the literature on the ploidy of Purkinje neurons and focuses on the special case of partial replication of their genome and on the unequal frequency of polyploid Purkinje neurons in the cerebellar cortex of the lobes and the vermis. Owing to the compartmental structure of the cerebellum, this paper suggests the investigation with modern methods and techniques of other cerebellar regions such as the flocculus, with the aim of establishing whether increased ploidy correlates with cell hypertrophy and/or with stimulation of cerebellar functions.

References

Jan 1, 1977·International Review of Cytology·W Y Brodsky, I V Uryvaeva
Jul 15, 1978·The Journal of Comparative Neurology·D M MannC M Barton
May 1, 1976·Journal of Neurobiology·R C Bohn, R B Mitchell
Dec 1, 1990·Alcoholism, Clinical and Experimental Research·R J Pentney, L J Quackenbush
Apr 1, 1974·Experimental Neurology·L Manuelidis, E E Manuelidis
Jun 1, 1970·Experimental Cell Research·V NovákováG Schlueter
Jul 10, 1999·Science·T GalitskiG R Fink
Apr 13, 2000·The European Journal of Neuroscience·M VecellioM R Celio
Jul 11, 2001·Genome Génome / Conseil National De Recherches Canada·A E VinogradovB N Kudryavtsev
Nov 29, 2001·The Journal of Cell Biology·J PrillerU Dirnagl
Mar 29, 2002·Nature·Mikhail V Blagosklonny, Arthur B Pardee
Oct 5, 2002·Cellular and Molecular Neurobiology·S Hossein FatemiAmelia Merz
Dec 14, 2002·Trends in Cell Biology·Jeffrey M Levsky, Robert H Singer
Jan 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Eva MezeyBarbara Crain
Feb 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·James M WeimannHelen M Blau
Apr 5, 2003·Circulation Research·Rossella GalliAngelo Luigi Vescovi
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth A Kellogg
Jul 29, 2003·The Cerebellum·Masao Ito
Nov 25, 2003·The Journal of Biological Chemistry·Matthew R Jones, Katya Ravid
May 26, 2004·Progress in Neurobiology·Constantino Sotelo
Mar 5, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stevens K RehenJerold Chun
Apr 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·M A KingsburyJ Chun

❮ Previous
Next ❯

Citations

Mar 23, 2011·Molecular and Cellular Neurosciences·K Amy ChenTong Zheng
Aug 26, 2010·The Journal of Comparative Neurology·Jurjen W WestraJerold Chun
Oct 11, 2011·The Journal of Pathology·Benjamin Lacroix, Amy Shaub Maddox
Apr 16, 2019·Journal of Neuroscience Research·Myrna A R Dent, Armando Aranda-Anzaldo
Apr 25, 2017·Journal of Alzheimer's Disease : JAD·Edward FielderDiana Jurk
Aug 26, 2020·ELife·Shyama NandakumarLaura A Buttitta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Comparative Neurology
D M MannC M Barton
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Gülin OzH B Clark
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Lorenzo MagrassiFerdinando Rossi
© 2021 Meta ULC. All rights reserved