The puzzling multiple lives of PML and its role in the genesis of cancer

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
D RuggeroP P Pandolfi

Abstract

PML, the gene associated with acute promyelocytic leukemia (APL); PML, the target of numerous viral agents; PML, the growth suppressor; PML, the mediator of multiple apoptotic pathways; PML, the tumor suppressor; PML, the protein which epitomizes a novel nuclear structure, the nuclear body; PML, the transcription co-factor. Despite the recent flurry of reports attributing multiple biological roles to the PML protein, PML still lacks a definitive biochemical function. This is probably the reason why PML is so attractive to many investigators. Here, we will summarize the facts and speculations on this puzzling protein.

References

Apr 28, 2004·Cytokine & Growth Factor Reviews·Dhananjaya V Kalvakolanu
May 6, 2003·Protein Expression and Purification·Francesco AntoliniMarco Sette
May 23, 2001·The Biochemical Journal·M Dundr, T Misteli
Jun 20, 2012·The Journal of Biological Chemistry·Sona HubackovaZdenek Hodny
Nov 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jiadi HuDhananjaya V Kalvakolanu
Oct 29, 2004·Molecular Biology of the Cell·Korie E HandwergerJoseph G Gall
Apr 25, 2002·Molecular and Cellular Biology·Gerardo FerbeyreScott W Lowe
Dec 26, 2001·Science's STKE : Signal Transduction Knowledge Environment·M Hatta, A Fukamizu
Feb 19, 2002·Oncogene·Jeremy D HensonRoger R Reddel
Mar 4, 2003·Nature Reviews. Cancer·Ian D Hickson
Jul 27, 2004·The Journal of Biological Chemistry·Jinwook ShinKwangseog Ahn
Sep 2, 2003·The Journal of Pathology·Chong Jai KimEun-Sil Yu
Jun 16, 2005·The FEBS Journal·Emili CidJoan J Guinovart
Jul 12, 2005·American Journal of Medical Genetics. Part a·Lisa J CushmanGail H Vance
Oct 5, 2001·The Journal of Biological Chemistry·M M KhanS Ishii
Mar 19, 2003·Oncogene·Hasan SekerCurtis C Harris
Jan 11, 2005·The Journal of Biological Chemistry·Gil BlanderLeonard Guarente
Oct 18, 2002·The Journal of Biological Chemistry·Gil BlanderMoshe Oren
Mar 21, 2003·Virchows Archiv : an International Journal of Pathology·Eunsil YuChong Jai Kim

Citations

Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M AlcalayF Lo Coco
Mar 1, 1991·The Journal of Cell Biology·C A Ascoli, G G Maul
Jun 1, 1995·The Journal of Experimental Medicine·J H LiuK S Chang
Oct 1, 1994·Molecular and Cellular Biology·Z M MuK S Chang
Oct 7, 1994·Science·P A FutrealY Miki
Jun 11, 1993·Annals of the New York Academy of Sciences·P S Freemont
Jun 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S BoufflerR Cox
Jan 5, 1996·The Journal of Biological Chemistry·X F LeK S Chang
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·K L BordenP S Freemont
Dec 17, 1997·Biochemical and Biophysical Research Communications·J Y ChanK S Chang
Mar 21, 1998·Science·Z G WangP P Pandolfi
Apr 21, 1998·Scandinavian Journal of Gastroenterology·K M RopponenV M Kosma
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·V J LaMorteR M Evans
Sep 12, 1998·Molecular Cell·J M DesterroR T Hay
Oct 3, 1998·The Journal of Biological Chemistry·T KamitaniE T Yeh
Nov 7, 1998·Nature Genetics·F QuignonH de Thé
Nov 7, 1998·Nature Genetics·Z G WangP P Pandolfi
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·V DoucasR M Evans
Jun 23, 1999·Current Opinion in Genetics & Development·J S Seeler, A Dejean

Related Concepts

Biochemical Pathway
Gene Expression Regulation, Neoplastic
Tumor Suppressor Genes
Cell Differentiation Process
Cell Division Phases
Mediator of activation protein
Nucleolar Proteins
Acute Promyelocytic Leukemia
Nuclear Structure
Intranuclear Body

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