The quality control assessment of commercially available coenzyme q(10)-containing dietary and health supplements in Japan

Journal of Clinical Biochemistry and Nutrition
Aikkarach KettawanTadashi Okamoto

Abstract

Coenzyme Q(10) (CoQ(10)) has been widely commercially available in Japan as a dietary and health supplement since 2001 and is used for the prevention of lifestyle-related diseases induced by free radicals and aging. We evaluated CoQ(10) supplements to ensure that these supplements can be used effectively and safely. Commercially available products were selected and assessed by the quality control tests specified in the Japanese Pharmacopoeia XV. When the disintegration time of CoQ(10) supplements was measured, a few tested supplements did not completely disintegrate even after incubation in water for an hour at 37 degrees C. In the content test, many samples were well controlled. However, a few supplements showed low recovery rates of CoQ(10) as compared to manufacturer's indicated contents. Among soft capsule and liquid supplements, the reduced form of CoQ(10) (H(2)CoQ(10)), as well as the oxidized form, was detected by HPLC with electrochemical detector. The results for experimental formulated CoQ(10) supplements demonstrated that H(2)CoQ(10) was produced by the interaction of CoQ(10) with vitamins E and/or C. From these results, we concluded that quality varied considerably among the many supplement brands containing CoQ(10)...Continue Reading

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Apr 10, 2008·Journal of Clinical Biochemistry and Nutrition·Aikkarach KettawanTadashi Okamoto

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Citations

Mar 20, 2010·Critical Reviews in Food Science and Nutrition·Igor PravstJanko Zmitek
Dec 16, 2010·The Journal of Pharmacy and Pharmacology·G Brian Lockwood
Nov 18, 2014·Clinical Pharmacology and Therapeutics·M M Reidenberg
Sep 16, 2020·Analytical Methods : Advancing Methods and Applications·Žane Temova RakušaRobert Roškar
Jul 29, 2016·The Journal of Pharmacy and Pharmacology·Manuela MartinefskiValeria Tripodi
Mar 7, 2021·Antioxidants·Žane Temova RakušaRobert Roškar

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