The quality of platelet concentrates produced by COBE Spectra and Trima Accel cell separators during storage for 7 days as assessed by in vitro methods

Transfusion
Nahreen TynngårdGösta Berlin

Abstract

The quality of platelet (PLT) concentrates (PCs) can be evaluated with various in vitro methods. A new technique, free oscillation rheometry (FOR), can be used to monitor coagulation properties of PCs and gives information on clotting time and coagulum elasticity. This study compared the quality of apheresis PCs produced by the COBE Spectra and Trima Accel cell separators (both Gambro BCT) during storage for 7 days with in vitro tests including FOR. Apheresis PCs were collected with the COBE Spectra (n = 10) and Trima Accel (n = 10) cell separators. Swirling, blood gases, and metabolic variables were analyzed on Day 0. Samples taken on Days 1, 5, and 7 were also analyzed for hypotonic shock response (HSR), P-selectin, and glycoprotein (GP)Ib expression and evaluation of coagulation by FOR. Swirling, HSR, and percent GPIb-expressing PLTs were well maintained for 7 days, whereas glucose decreased and lactate increased significantly during storage for both Spectra and Trima PCs. Percent P-selectin-expressing cells increased to the same extent in both types of PCs during storage. pH increased between Day 0 and Day 1 but then decreased. The clotting time remained constant throughout the storage period whereas the development of elas...Continue Reading

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Citations

Aug 25, 2009·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Nahreen Tynngård
Aug 25, 2009·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Tomas L Lindahl, Sofia Ramström
May 16, 2009·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·O Garraud, F Cognasse
Jun 26, 2010·Transfusion·Nahreen TynngårdGösta Berlin
Nov 3, 2011·Transfusion·Nahreen TynngårdGösta Berlin
Jun 15, 2011·Vox Sanguinis·S Panzer, P Jilma
Feb 18, 2015·Thrombosis Journal·Nahreen TynngårdSofia Ramström
Jan 31, 2018·Transfusion·Timo F SeyfriedErnil Hansen
Aug 3, 2014·Journal of Cardiothoracic Surgery·Brian A BrucknerMatthias Loebe

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