The quantitative LOD score: test statistic and sample size for exclusion and linkage of quantitative traits in human sibships

American Journal of Human Genetics
G P PageE Boerwinkle

Abstract

We present a test statistic, the quantitative LOD (QLOD) score, for the testing of both linkage and exclusion of quantitative-trait loci in randomly selected human sibships. As with the traditional LOD score, the boundary values of 3, for linkage, and -2, for exclusion, can be used for the QLOD score. We investigated the sample sizes required for inferring exclusion and linkage, for various combinations of linked genetic variance, total heritability, recombination distance, and sibship size, using fixed-size sampling. The sample sizes required for both linkage and exclusion were not qualitatively different and depended on the percentage of variance being linked or excluded and on the total genetic variance. Information regarding linkage and exclusion in sibships larger than size 2 increased as approximately all possible pairs n(n-1)/2 up to sibships of size 6. Increasing the recombination (theta) distance between the marker and the trait loci reduced empirically the power for both linkage and exclusion, as a function of approximately (1-2theta)4.

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Citations

Sep 7, 2006·Genetica·Loren H RiesebergKeith Clay
Jul 16, 2010·Journal of Evolutionary Biology·S R Keller, D R Taylor
Jul 5, 2012·Evolution; International Journal of Organic Evolution·Ilkka KronholmJuliette de Meaux
Dec 18, 2012·Journal of Evolutionary Biology·M BjörklundL Gustafsson
Jul 25, 2014·Proceedings. Biological Sciences·Belinda van Heerwaarden, Carla M Sgrò
Sep 14, 2018·Proceedings. Biological Sciences·Evatt ChirgwinKeyne Monro
Aug 14, 2013·Genetics Research·James J Lee, Carson C Chow
Apr 20, 2014·Human Genetics·James J Lee, Carson C Chow
May 2, 2001·Statistical Methods in Medical Research·C I Amos, M de Andrade
Nov 30, 2018·Ophthalmic Genetics·Paulo Vinicius SvidnickiMônica Barbosa de Melo

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