PMID: 6420536Dec 1, 1983

The quantitative transperitoneal absorption of a fat emulsion: implications for intraperitoneal nutrition

Journal of Pediatric Surgery
M D KleinJ R Wesley

Abstract

Intraperitoneal (IP) administration of nutrients would be an attractive alternative to intravenous nutrition since it eliminates intravascular complications. If glucose alone were used as the nonprotein calorie source, associated fluid shifts might not be well tolerated by the patient. A fat emulsion does not have osmotic properties and thus might be incorporated into a program of IP nutrition as a calorie source. Transperitoneal absorption of a commercial fat emulsion (Liposyn 10%, Abbott Laboratories, N Chicago, IL) was studied in 12 beagle puppies divided into two groups. One group received 2.5 gm/kg of fat and the other group received a similar volume of 3.5% crystalline amino acids and 5% glucose in one IP dose. In the first group, the serum triglyceride (TG) increased three fold from 61 +/- 25 mg% to 185 +/- 61 mg% at 15 minutes and then decreased slowly while remaining significantly elevated (p less than 0.05) at 4 hours. 1.94 +/- 0.20 gm/kg of TG were absorbed from the peritoneal cavity over 4 hours. Concommitant IP administration of amino acids and glucose did not affect that absorption. Radiolabeled amino acids and glucose instilled IP were demonstrated in the blood immediately after administration and their absorptio...Continue Reading

References

Jan 1, 1976·The Journal of Clinical Investigation·K N Jeejee hoyE B Marliss
Nov 23, 1973·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·G Szabó, Z Magyar
Nov 1, 1966·American Journal of Surgery·R M Zollinger, R Passi
Feb 1, 1981·Metabolism: Clinical and Experimental·D S SchadeP W Day
Mar 18, 1982·The New England Journal of Medicine·P AmairD Oreopoulos
Mar 22, 1894·The Journal of Physiology·E H Starling, A H Tubby

Citations

Feb 1, 1990·American Journal of Surgery·E S AdkinsE W Fonkalsrud
Mar 1, 1986·Journal of Pediatric Surgery·M M StoneE W Fonkalsrud
Dec 1, 1985·Journal of Pediatric Surgery·M D KleinJ R Wesley
Sep 21, 2010·JPEN. Journal of Parenteral and Enteral Nutrition·Igor SukhotnikRon Shaoul
Jan 1, 1988·JPEN. Journal of Parenteral and Enteral Nutrition·M E PessaT G Baumgartner
Nov 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·J MoranL Garcia-Sancho
Nov 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·J MoranL Vinagre

Related Concepts

Process of Absorption
Blood Glucose
Canis familiaris
Fat Emulsions, Intravenous
Glucagon
Glycerin
Parenteral Nutrition
Greater Sac of Peritoneum
Visceral Peritoneum
Triglycerides

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