PMID: 9525595Apr 3, 1998Paper

The quantity of latent viral DNA correlates with the relative rates at which herpes simplex virus types 1 and 2 cause recurrent genital herpes outbreaks

Journal of Virology
J A Lekstrom-HimesS E Straus

Abstract

Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) have evolved specific anatomic tropisms and site-dependent rates of reactivation. To determine whether reactivation rates depend on distinct abilities of HSV-1 and -2 to establish latency and to express latency-associated transcripts (LATs), virulent strains of each virus were studied in the guinea pig genital model. Following infection with equivalent titers of virus, the quantities of latent HSV-2 genomes and LATs were higher in lumbosacral ganglia, and HSV-2 infections recurred more frequently and lasted longer than HSV-1 infections. In contrast, if the inoculum of HSV-1 was 10 times that of HSV-2, the quantity of HSV-1 DNA and LATs increased correspondingly and HSV-1 infections were as likely to recur as those with HSV-2. The quantity of latent virus DNA correlates with and may be a major determinant of the site-specific patterns and rates of reactivation of HSV-1 and -2.

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Citations

Aug 16, 2002·American Journal of Clinical Dermatology·Arjen F Nikkels, Gérald E Pièrard
Jan 18, 2008·The Journal of Infectious Diseases·David M Koelle, Tracy L Bergemann
May 13, 2008·The Journal of Infectious Diseases·Christine JohnstonAnna Wald
Jan 21, 2000·The Journal of General Virology·C M Preston
Sep 15, 2001·Brain Pathology·R J Cohrs, D H Gilden
Jul 24, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anthony J St LegerRobert L Hendricks
Sep 23, 2000·Journal of the American Academy of Nurse Practitioners·C A Fitzpatrick
Dec 3, 2011·The Journal of Clinical Investigation·Christine JohnstonAnna Wald
Feb 5, 2003·Sexually Transmitted Diseases·Rebecca EngelbergAnna Wald
Jan 15, 2003·Clinical Microbiology Reviews·David M Koelle, Lawrence Corey
Aug 21, 2012·Sexually Transmitted Diseases·Frances ValenciaNigel Bourne
Dec 14, 2011·Journal of Neurovirology·Anthony J St Leger, Robert L Hendricks
Nov 2, 2018·The Journal of Infectious Diseases·Meena S RamchandaniDavid M Koelle
Jul 22, 2008·Diagnostic Microbiology and Infectious Disease·Robert N BowlesJohn A Blaho

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