The Quest for MAP Kinase Substrates: Gaining Momentum

Trends in Plant Science
Róbert Dóczi, László Bögre

Abstract

Mitogen-activated protein kinase (MAPK) pathways are versatile signaling mechanisms in all eukaryotes. Their signaling outputs are defined by the protein substrates phosphorylated by MAPKs. An expanding list of substrates has been identified by high-throughput screens and targeted approaches in plants. The majority of these are phosphorylated by MPK3/6, and a few by MPK4, which are the best-characterized plant MAPKs, participating in the regulation of numerous biological processes. The identified substrates clearly represent the functional diversity of MAPKs: they are associated with pathogen defense, abiotic stress responses, ethylene signaling, and various developmental functions. Understanding their outputs is integral to unraveling the complex regulatory mechanisms of MAPK cascades. We review here methodological approaches and provide an overview of known MAPK substrates.

Citations

Jul 22, 2019·The Plant Journal : for Cell and Molecular Biology·Wei ZhangEmmanuel Baudouin
Mar 13, 2019·Scientific Reports·Balázs KalaposRóbert Dóczi
May 28, 2020·Journal of Integrative Plant Biology·Xiangxiong DengJuan Xu
Jun 27, 2019·Nature Plants·Huachun Larue, Shuqun Zhang
Jan 29, 2020·Journal of Chemical Ecology·Laquita GrissettJohannes W Stratmann
Dec 15, 2020·Journal of Experimental Botany·Simon Mitreiter, Tamara Gigolashvili
Oct 30, 2020·International Journal of Molecular Sciences·Julien Lang, Jean Colcombet
Feb 11, 2021·International Journal of Molecular Sciences·Jie ChenMeng Yuan
Oct 8, 2021·The New Phytologist·Yang XiangAying Zhang

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