The Quest for Off-the-Shelf CAR T Cells

Cancer Discovery

Abstract

Various companies are exploring ways to manufacture allogeneic chimeric antigen receptor T cells, which could then be administered off the shelf to multiple recipients, thereby expanding access to this immunotherapy. However, challenges, such as finding ways to address the twin complications of graft-versus-host disease and host rejection of the therapeutic product, remain.

Citations

Nov 2, 2018·Human Vaccines & Immunotherapeutics·Richard BurtAdele K Fielding
May 11, 2019·Clinical & Translational Immunology·Sherly MardianaPhillip Kevin Darcy
Nov 26, 2020·Archives of Pathology & Laboratory Medicine·Allison M Cushman-VokounSophia Yohe
Feb 10, 2020·Bulletin du cancer·Audrey GrainAndré Baruchel

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