PMID: 7518359Jan 1, 1994Paper

The quinoline-3-carboxamide linomide inhibits angiogenesis in vivo

Cancer Chemotherapy and Pharmacology
P BorgströmB Hartley-Asp

Abstract

Linomide (Roquinimex) has antitumor activity when given in vivo (but not when applied in vitro) that has been attributed to immune host mechanisms. Recent studies, however, suggest that Linomide may also possess antiangiogenic properties. The aim of the present study was to evaluate the antiangiogenic effect of Linomide using an intravital microscopic technique. Syngeneic pancreatic islets were isolated and implanted into the dorsal skinfold chamber of Syrian golden hamsters. This model allows detailed repeated in vivo observations and quantitative analysis of revascularization of pancreatic islet grafts. The neovascularization process of the islets is a highly reproducible phenomenon that is completed within about 2 weeks, resulting in a microvascular network very similar to that of islets in situ. The plasma concentration profile of Linomide following a single oral dose of the compound was determined. The elimination of Linomide was fast, the half-life being 2.6 +/- 0.2 h. Due to the short half-life, the hamsters were given Linomide twice a day. One group of animals (n = 9) was force-fed Linomide (100 mg/kg per day) from the day of implantation throughout the 2-week observation period, and the results were compared with those...Continue Reading

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Jul 1, 1997·Cancer Treatment Reviews·A P Jekunen, K J Kairemo
Sep 16, 2003·Transplantation·Leila MakhloufMohamed H Sayegh
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Oct 16, 2004·Molecular and Cellular Biology·Piyali DasguptaSrikumar P Chellappan

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