The quinoprotein dehydrogenases for methanol and glucose

Archives of Biochemistry and Biophysics
Christopher Anthony

Abstract

This review summarises our current understanding of two of the main types of quinoprotein dehydrogenase in which pyrroloquinoline quinone (PQQ) is the only prosthetic group. These are the soluble methanol dehydrogenase and the membrane glucose dehydrogenase (mGDH). The membrane GDH has an additional N-terminal domain by which it is tightly anchored to the membrane, and a periplasmic domain whose structure has been modelled on the X-ray structure of the alpha-subunit of MDH which contains PQQ in the active site. This review discusses their structures and mechanisms, concentrating particularly on the pathways for electron transfer from the reduced PQQ, through the protein, to their electron acceptors. In MDH, this is the specific cytochrome c(L), the electron transfer pathway probably involving the unique disulphide ring in the active site. By contrast, mGDH contains a permanently bound ubiquinone, which acts as a single electron carrier, mediating electron transfer through the protein to the membrane ubiquinone.

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Citations

Jul 13, 2011·Inorganic Chemistry·Wolfgang Kaim
May 8, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Goutam Kumar Lahiri, Wolfgang Kaim
Jul 22, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Dipanwita DasGoutam Kumar Lahiri
Dec 23, 2008·Antioxidants & Redox Signaling·Gloria Saab-Rincón, Brenda Valderrama
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Jun 12, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Wolfgang Nitschke, Michael J Russell
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Jul 6, 2013·Applied Microbiology and Biotechnology·Jessica ZeiserUwe Deppenmeier
Nov 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Swarnalatha Y Reddy, Thomas C Bruice
Mar 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Christopher W M KayRobert Bittl
May 13, 2014·Applied Microbiology and Biotechnology·Jan T KeltjensHuub J M Op den Camp
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Jun 9, 2015·Applied Microbiology and Biotechnology·Ludmila Chistoserdova
Jan 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Xiaodong ZhangThomas C Bruice
Jul 1, 2016·World Journal of Microbiology & Biotechnology·Ludmila Chistoserdova

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