The quorum sensing peptides PhrG, CSP and EDF promote angiogenesis and invasion of breast cancer cells in vitro

PloS One
Bart De SpiegeleerEvelien Wynendaele

Abstract

The role of the human microbiome on cancer progression remains unclear. Therefore, in this study, we investigated the influence of some quorum sensing peptides, produced by diverse commensal or pathogenic bacteria, on breast cancer cell invasion and thus cancer outcome. Based on microscopy, transcriptome and Chick Chorioallantoic Membrane (CAM) analyses, four peptides (PhrG from B. subtilis, CSP from S. mitis and EDF from E. coli, together with its tripeptide analogue) were found to promote tumour cell invasion and angiogenesis, thereby potentially influencing tumour metastasis. Our results offer not only new insights on the possible role of the microbiome, but also further opportunities in cancer prevention and therapy by competing with these endogenous molecules and/or by modifying people's life style.

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Citations

Nov 5, 2015·PloS One·Evelien WynendaeleBart De Spiegeleer
Aug 6, 2016·Future Microbiology·Gregor Reid
Nov 8, 2016·Functional & Integrative Genomics·Bugra Ozer, Ugur Sezerman
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Dec 27, 2016·Frontiers in Physiology·Alejandra V ContrerasOsbaldo Resendis-Antonio
Apr 28, 2017·Frontiers in Neuroscience·Frederick VerbekeBart De Spiegeleer
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Mar 3, 2020·Frontiers in Oncology·Zahra Eslami-SRezvan Esmaeili
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May 15, 2021·Seminars in Cancer Biology·Vipin Chandra KaliaJung-Kul Lee
May 23, 2021·Scientific Reports·Yorick JanssensBart De Spiegeleer
Oct 13, 2021·Annals of the New York Academy of Sciences·Jakub P PiwowarskiSebastian Granica

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Datasets Mentioned

BETA
A2224
A2080
E-MTAB-3191

Methods Mentioned

BETA
X-ray

Software Mentioned

ImageJ
MassLynx
ArrayExpress
Affymetrix
MetaCore (
Waters Empower Pro
Transcriptome Analysis Console (

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