PMID: 9651468Jul 4, 1998Paper

The R8-photoreceptor equivalence group in Drosophila: fate choice precedes regulated Delta transcription and is independent of Notch gene dose

Mechanisms of Development
Nicholas E Baker, S Y Yu

Abstract

It has been suggested that lateral specification of cell fate by Notch signaling depends on feedback on Notch (N) and Delta (Dl) transcription to establish reciprocal distributions of the receptor and its ligand at the protein level. In Drosophila neurogenesis the predicted reciprocal protein distributions have not been observed. Either this model of lateral specification or the description of N and/or Dl protein distributions must be incomplete. We have reexamined R8 photoreceptor specification in the developing eye to resolve this question for this example of lateral specification. N and Dl protein levels were assessed in the cell as a whole and at the cell surface, where these proteins were mostly found at the intercellular cell junctions. Protein levels did not correspond to Notch signaling in wild type. However, Dl transcription and protein levels did correlate with altered N signaling in mutant genotypes. Our findings suggest the difference relates to the speed of lateral specification in vivo. The time required for N signaling to inhibit ato expression was at most 90 min, but changes in the Dl protein distribution in mutant genotypes arose more slowly. N expression was little regulated by N signaling, but protein encoded...Continue Reading

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Citations

Feb 23, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N E Baker
Sep 24, 2010·The European Physical Journal. E, Soft Matter·M W Pennington, D K Lubensky
Dec 24, 2010·PloS One·Randy S BoylesAndrew J Andres
Jun 27, 2009·The International Journal of Developmental Biology·Jean-Yves Roignant, Jessica E Treisman
Jul 25, 2008·Development Genes and Evolution·Jean-François Le Garrec, Michel Kerszberg
Mar 24, 2004·Seminars in Cell & Developmental Biology·Chonnettia Jones, Kevin Moses
Apr 30, 2008·Genesis : the Journal of Genetics and Development·Annette L ParksMarc A T Muskavitch
Dec 12, 2001·Seminars in Cell & Developmental Biology·N E Baker
Dec 22, 2004·The Journal of Cell Biology·Francois AhimouCedric Wesley
Apr 8, 2014·Methods : a Companion to Methods in Enzymology·Evanthia Zacharioudaki, Sarah J Bray
Feb 8, 2008·Development·Suk Ho EunJanice A Fischer

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