The rabbit as a model to study asthma and other lung diseases

Pulmonary Pharmacology & Therapeutics
Sandra Keir, Clive Page

Abstract

No single animal model is able to reproduce all the features of human asthma. However, the similarities between neonatally immunised rabbits and human asthma highlight the value of this model in the investigation of asthma pathophysiology and in the development of therapeutic agents. Airway inflammation and airway responses to various stimuli including histamine, adenosine 5'monophosphte and antigen in allergic rabbits have shown similarities with the responses observed in asthmatics. Furthermore, functional studies in rabbit airways show they are poorly responsive to capsaicin as are human airways. Chronic pre-treatment with capsaicin desensitises the TRPV(1) receptor enabling studies into the effect of this drug in both rabbits and man. The allergic rabbit model has been used extensively in assessing the various classes of anti-asthma drugs and is sensitive to similar drugs as patients with asthma, including beta-adrenoceptor agonists, corticosteroids, phosphodiesterase inhibitors and theophylline. This article highlights the usefulness of the rabbit as a species to study lung biology.

References

May 1, 1977·Clinical Allergy·D W CockcroftF E Hargreave
Aug 1, 1990·The American Review of Respiratory Disease·R DjukanovićS T Holgate
Jan 1, 1987·Annual Review of Physiology·G Sant'Ambrogio
Jul 1, 1988·British Journal of Clinical Pharmacology·N M RobertsP J Barnes
May 1, 1987·The Journal of Allergy and Clinical Immunology·J R BrittonA E Tattersfield
Oct 1, 1985·The Journal of Allergy and Clinical Immunology·R PauwelsC G Persson
Nov 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·D C ZavalaW E Connor
Jan 1, 1973·Respiration; International Review of Thoracic Diseases·B G SimonssonN Svedmyr
Feb 1, 1983·British Journal of Clinical Pharmacology·M J CushleyS T Holgate
Apr 1, 1983·Laboratory Animals·P A FlecknellS Simpkin
Jul 1, 1994·Respiratory Medicine·A J WardJ F Costello
Nov 1, 1994·American Journal of Respiratory and Critical Care Medicine·P K Jeffery
Aug 1, 1994·The European Respiratory Journal·G J DouglasC P Page
Jan 1, 1994·British Journal of Pharmacology·C M HerdC P Page
Dec 1, 1993·Journal of Pharmacological and Toxicological Methods·E M MinshallC P Page
Apr 1, 1994·Human & Experimental Toxicology·I DrakeR Richards
Dec 2, 1993·Nature·B J Sutton, H J Gould
Jan 1, 1993·The American Review of Respiratory Disease·L M KuitertN C Barnes
Feb 1, 1993·The American Review of Respiratory Disease·N CarrollA James
Mar 1, 1993·The American Review of Respiratory Disease·A J WardJ F Costello
May 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R DjukanovićP H Howarth
Feb 20, 1997·Nature·J W Nyce, W J Metzger
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·D J EvansB J O'Connor

❮ Previous
Next ❯

Citations

Jul 9, 2013·Biochemical Pharmacology·Kevin Mullane, Michael Williams
May 9, 2013·BioMed Research International·Nurfatin Asyikhin KamaruzamanBadrul Hisham Yahaya
May 28, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Richard W Weber
Feb 24, 2016·Molecular and Cellular Probes·Fa-Ping WangHui Mao
Nov 4, 2015·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Laura LossiAdalberto Merighi
Feb 4, 2016·The Journal of Pharmacology and Experimental Therapeutics·Emlyn ClayClive Page
Aug 1, 2012·Reproduction in Domestic Animals = Zuchthygiene·A Bähr, E Wolf
Jul 1, 2017·International Journal of Inflammation·N A KamalaldinB Yahaya
Oct 19, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Carl T D'Angio, Rita M Ryan
Jun 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ayman M MousaSaleh A Almatroodi
Nov 18, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Erica FerriniFranco Fabio Stellari
Oct 20, 2020·British Journal of Anaesthesia·André Dos Santos RochaWalid Habre

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Related Papers

Current Drug Targets
Fabio L M RicciardoloGert Folkerts
Pulmonary Pharmacology & Therapeutics
William M Abraham
Pulmonary Pharmacology & Therapeutics
Charles G Plopper, Dallas M Hyde
The Journal of Experimental Medicine
Robert L Coffman, Edith M Hessel
© 2022 Meta ULC. All rights reserved