The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration

Blood
Audrey GérardJohn G Collard

Abstract

Migration toward chemoattractants is a hallmark of T-cell trafficking and is essential to produce an efficient immune response. Here, we have analyzed the function of the Rac activator Tiam1 in the control of T-cell trafficking and transendothelial migration. We found that Tiam1 is required for chemokine- and S1P-induced Rac activation and subsequent cell migration. As a result, Tiam1-deficient T cells show reduced chemotaxis in vitro, and impaired homing, egress, and contact hypersensitivity in vivo. Analysis of the T-cell transendothelial migration cascade revealed that PKCzeta/Tiam1/Rac signaling is dispensable for T-cell arrest but is essential for the stabilization of polarization and efficient crawling of T cells on endothelial cells. T cells that lack Tiam1 predominantly transmigrate through individual endothelial cells (transcellular migration) rather than at endothelial junctions (paracellular migration), suggesting that T cells are able to change their route of transendothelial migration according to their polarization status and crawling capacity.

References

May 25, 1995·Nature·F MichielsJ G Collard
Apr 4, 1998·The Journal of Experimental Medicine·D FengA M Dvorak
May 4, 1999·The Journal of Experimental Medicine·C Berlin-RufenachN Hogg
Oct 6, 2000·The New England Journal of Medicine·U H von Andrian, C R Mackay
Dec 6, 2001·Nature Reviews. Molecular Cell Biology·M Fukata, K Kaibuchi
Dec 13, 2002·Nature·Sandrine Etienne-Manneville, Alan Hall
Jan 14, 1964·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·V T MARCHESI, J L GOWANS
Oct 2, 2003·Current Opinion in Cell Biology·Angeliki Malliri, John G Collard
Sep 18, 2004·European Journal of Immunology·Britta Engelhardt, Hartwig Wolburg
Oct 22, 2004·The Biochemical Journal·Jaime Millán, Anne J Ridley
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guy CinamonRonen Alon
Dec 18, 2004·Current Opinion in Hematology·Erika S WittchenRebecca A Worthylake
Dec 25, 2004·Blood·Miguel Vicente-ManzanaresFrancisco Sánchez-Madrid
Feb 22, 2005·Nature Cell Biology·Takashi NishimuraKozo Kaibuchi
Feb 22, 2005·Nature Cell Biology·Xinyu Chen, Ian G Macara
Mar 18, 2005·Annual Review of Immunology·Jason G Cyster
May 6, 2005·Molecular Biology of the Cell·David García-BernalJoaquin Teixidó
Aug 20, 2005·Immunology·Jens V Stein, César Nombela-Arrieta
Jan 24, 2006·Nature Cell Biology·Mikko NieminenSirpa Jalkanen
May 3, 2006·Trends in Cell Biology·Alexander E E MertensJohn G Collard
Feb 28, 2007·The Journal of Experimental Medicine·César Nombela-ArrietaJens V Stein
Mar 14, 2007·The Journal of Cell Biology·Audrey GérardJohn G Collard
May 8, 2007·Trends in Immunology·Federica M Marelli-BergVincenzo Mirenda
Jun 16, 2007·Immunity·Christopher V CarmanTimothy A Springer
Jul 13, 2007·Immunological Reviews·Adam MorMark R Philips
Aug 25, 2007·Nature Reviews. Immunology·Klaus LeySussan Nourshargh
Nov 21, 2007·Nature Immunology·Susan R Schwab, Jason G Cyster
Aug 20, 2008·Nature Immunology·Marcus Thelen, Jens V Stein

❮ Previous
Next ❯

Citations

Jul 26, 2011·Histochemistry and Cell Biology·Sara SolinetMaría Leiza Vitale
Apr 24, 2010·Nature Reviews. Molecular Cell Biology·Sussan NoursharghMichael Sixt
Oct 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Bettina StolpOliver T Fackler
Aug 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Tara M StruttSusan L Swain
Feb 18, 2012·The Journal of Biological Chemistry·Onetsine ArrizabalagaJosé L Zugaza
Nov 6, 2009·The Journal of Experimental Medicine·Zahra MamdouhWilliam A Muller
Nov 14, 2012·The Journal of Experimental Medicine·Lin ZhangSteffen Massberg
Oct 30, 2009·Current Opinion in Hematology·Abigail WoodfinSussan Nourshargh
Dec 10, 2009·Current Opinion in Hematology·Masataka Kamei, Christopher V Carman
Sep 26, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Elvira Infante, Anne J Ridley
Oct 21, 2011·Physiology·Eric P SchmidtGregory P Downey
Jan 25, 2013·Veterinary Pathology·W A Muller
May 23, 2014·Cellular and Molecular Life Sciences : CMLS·Yulia ArtemenkoPeter N Devreotes
Nov 16, 2010·Annual Review of Pathology·William A Muller
Aug 6, 2014·The Journal of Experimental Medicine·Sachin KumarMarie-Dominique Filippi
Feb 13, 2013·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Megan B MillerRichard E Mains
Sep 6, 2012·Journal of Vascular Research·Ruth Lyck, Britta Engelhardt
Feb 26, 2016·Frontiers in Immunology·Claire Hivroz, Michael Saitakis
Jan 23, 2016·Cellular and Molecular Life Sciences : CMLS·Peter L Hordijk
Mar 5, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Ming-Tai LinMei-Hwan Wu
Dec 31, 2011·Immunology Letters·Pablo Rougerie, Jérôme Delon
Oct 22, 2011·Molecular Immunology·Mohamed Ali JarbouiVirginie W Gautier
Dec 5, 2015·Frontiers in Immunology·Christopher V Carman, Roberta Martinelli
Oct 10, 2015·Tissue Barriers·Marie-Dominique Filippi
Nov 18, 2014·Biochemical Society Transactions·Aideen Long, Michael Freeley
Jul 21, 2010·Developmental Cell·Chris D Madsen, Erik Sahai
Sep 28, 2010·Blood·Mustapha FaroudiVictor L J Tybulewicz
Jan 17, 2015·Nucleic Acids Research·Bi-Huei YangJochen Huehn
May 10, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Antje SchaeferPeter L Hordijk
Oct 4, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y Maurice MorillonRoland Tisch
Oct 6, 2016·F1000Research·Debashree Goswami, Dietmar Vestweber
May 30, 2019·Physiological Reviews·Nina WettschureckStefan Offermanns
Aug 4, 2020·Advanced Biosystems·Parthiv Kant ChaudhuriLance C Kam
Aug 31, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mikaela GrönholmCarl G Gahmberg
Feb 20, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas D Manes, Jordan S Pober
Dec 22, 2016·Science Signaling·Carlo Cosimo CampaEmilio Hirsch

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