The racial disparity in outcomes in endometrial cancer: could this be explained on a molecular level?

Gynecologic Oncology
Veronica SchimpAdnan R Munkarah

Abstract

The racial disparities among patients with endometrial carcinoma have been previously reported. The objective of this study is to analyze and compare the molecular profiles in endometrial cancer in Caucasian and African American patients using a number of known molecular markers. 147 patients diagnosed with endometrial cancer between 1995 and 2001 were included in the study. Patients' demographics, clinical and pathological data were reviewed. Immunohistochemical staining for p53, VEGF, Ki-67 and HIF-1alpha was performed on tissue micro array sections. Tumors' expression of p53, VEGF, Ki-67, and HIF-1alpha was compared based on ethnicity and tumor type (Type I = endometrioid carcinomas and Type II = non-endometrioid carcinomas). Spearman's correlation and Fisher's Exact Tests were used for statistical analysis and Kaplan-Meier, log-rank and Cox regression were used for survival analysis. 97 patients were Caucasian and 50 patients were African American. The mean age was 62 (33-91) years for Caucasian patients and 63.5 (24-89) years for the African American patients. African American patients had more Type II carcinoma than Caucasian patients (P = 0.055). High p53 expression was statistically significant among the African America...Continue Reading

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Citations

Feb 20, 2010·Obstetrics and Gynecology International·Laura M S SeeberPaul J van Diest
Sep 25, 2009·Archives of Gynecology and Obstetrics·Mine Kanat-PektasUmit Bilge
Oct 30, 2012·Gynecologic Oncology·Mohamed A ElshaikhFarzan Siddiqui
Mar 8, 2011·Gynecologic Oncology·Zaid Al-WahabAdnan R Munkarah
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