The radial arrangement of the human chromosome 7 in the lymphocyte cell nucleus is associated with chromosomal band gene density.

Chromosoma
Concetta FedericoSalvatore Saccone

Abstract

In the nuclei of human lymphocytes, chromosome territories are distributed according to the average gene density of each chromosome. However, chromosomes are very heterogeneous in size and base composition, and can contain both very gene-dense and very gene-poor regions. Thus, a precise analysis of chromosome organisation in the nuclei should consider also the distribution of DNA belonging to the chromosomal bands in each chromosome. To improve our understanding of the chromatin organisation, we localised chromosome 7 DNA regions, endowed with different gene densities, in the nuclei of human lymphocytes. Our results showed that this chromosome in cell nuclei is arranged radially with the gene-dense/GC-richest regions exposed towards the nuclear interior and the gene-poorest/GC-poorest ones located at the nuclear periphery. Moreover, we found that chromatin fibres from the 7p22.3 and the 7q22.1 bands are not confined to the territory of the bulk of this chromosome, protruding towards the inner part of the nucleus. Overall, our work demonstrates the radial arrangement of the territory of chromosome 7 in the lymphocyte nucleus and confirms that human genes occupy specific radial positions, presumably to enhance intra- and inter-ch...Continue Reading

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Citations

Jun 23, 2011·Chromosoma·Romain SolinhacMartine Yerle-Bouissou
Sep 29, 2011·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Dimitris IoannouDarren Karl Griffin
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Mar 10, 2010·Genome Research·Louise HarewoodAlexandre Reymond
Nov 26, 2015·Human Molecular Genetics·Nitasha SehgalRonald Berezney
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Oct 6, 2015·Annual Review of Genetics·Huy Q Nguyen, Giovanni Bosco
Aug 23, 2008·Biochimica Et Biophysica Acta·Elena Fedorova, Daniele Zink
Sep 16, 2008·Biochimica Et Biophysica Acta·Siwei YangKarl Rohr
Nov 20, 2010·Cytogenetic and Genome Research·D Ioannou, D K Griffin
Jul 19, 2017·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Concetta FedericoSalvatore Saccone
Jan 22, 2019·Genes, Chromosomes & Cancer·Andrew J FritzRonald Berezney
Jan 16, 2010·Biochemical Society Transactions·Poonam MalikEric C Schirmer
Sep 20, 2018·Journal of Assisted Reproduction and Genetics·Zaida SarrateJoan Blanco

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