The radioprotective effects of the hexane and ethyl acetate extracts of Callophyllis japonica in mice that undergo whole body irradiation.

Journal of Veterinary Science
Jeongtae KimTaekyun Shin

Abstract

The radioprotective activity of extracts from the red seaweed Callophyllis (C.) japonica was investigated in mice that underwent whole-body exposure to gamma radiation. A methanol extract of C. japonica and its fractions [hexane, ethyl acetate (EtOAc), butanol and the remaining H2O] were used. Each fraction (100 mg/kg body weight) was administered intraperitoneally (i.p.) 2 times into the BALB/c mice, once at 1 and once at 24 h before exposure to 9 Gray (Gy) of gamma radiation. Pre-irradiation administration of the hexane and EtOAc fractions saved the mice, with their survival rates being greater than 80% at 30 days post-irradiation; the mice that were pretreated with the other fractions showed survival rates lower than 20% over the same time period. To examine the effect of each C. japonica fraction on the survival of intestinal and bone marrow stem cells, the number of intestinal crypts and bone marrow cells in the gamma-irradiated mice were examined. Pre-treatment of mice (i.p., 100 mg/kg body weight at 1 and 24 h before irradiation) with the hexane or EtOAc fraction prior to 6-Gy irradiation significantly protected the number of jejunal crypts and bone marrow cells at 9 days after irradiation. These findings suggest that ce...Continue Reading

References

Jan 1, 1970·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·H R Withers, M M Elkind
Nov 1, 1996·International Journal of Radiation Biology·M M WeilK A Mason
Jun 8, 2001·Journal of Radiation Research·C K NairT Nomura
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Aug 23, 2005·Phytotherapy Research : PTR·Kyoung Ah KangJin Won Hyun
Jan 6, 2006·Journal of Radiation Research·Yong Zhou, Man-Tian Mi
Oct 16, 2007·Drug Discovery Today·Seyed Jalal Hosseinimehr
Nov 13, 2007·Journal of Veterinary Science·Heechul KimTaekyun Shin

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Citations

Dec 18, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Meejung AhnTaekyun Shin
Dec 5, 2009·Phytotherapy Research : PTR·Changjong MoonTaekyun Shin

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