PMID: 3759535Oct 1, 1986Paper

The radiosensitizing effects of misonidazole (MISO) in combination with diethyl maleate (DEM) in mouse mammary tumors

International Journal of Radiation Oncology, Biology, Physics
K OnoD C Shrieve

Abstract

Large radiosensitization of C3H/He mouse mammary tumors was obtained with the combination of a non-protein sulfhydryl (NPSH) depletor, diethyl maleate (DEM), and misonidazole (MISO), compared with MISO alone over a range of MISO dose. The difference in enhancement ratios (ER's) for these two treatments was especially prominent at small MISO doses. ER's of 2.06 and 1.44 were obtained, respectively, by combined treatment with DEM (760 mg/kg) and MISO (100 mg/kg) or treatment with MISO alone. Radiosensitization of tumors by DEM alone was observed for doses over 600 mg/kg. When DEM was combined with MISO (100 mg/kg), ER's of the combination were larger than that of MISO alone, for doses over 400 mg/kg of DEM. Similarly, in case of DEM plus MISO (300 mg/kg), the ER's became larger than MISO alone, for doses over 200 mg/kg of DEM. The NPSH content in untreated tumors was 1.08 mmole/kg on the average and no changes in NPSH content was observed after MISO treatment. DEM treatment markedly reduced the NPSH content of tumors as a function of DEM dose and this decrease in NPSH was not significantly affected by MISO treatment. Tumor NPSH was reduced to 24% or less of control by administration of 760 mg/kg of DEM with or without MISO. These...Continue Reading

References

Jul 1, 1969·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·G E Adams, M S Cooke
Aug 1, 1984·International Journal of Radiation Oncology, Biology, Physics·N Y Yu, J M Brown
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Jan 20, 1950·The Journal of General Physiology·E S G BARRON, V FLOOD

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Citations

Jan 1, 1988·Pharmacology & Therapeutics·M R StratfordR R Watfa
Jan 1, 1990·Pharmacology & Therapeutics·E A Bump, J M Brown
Nov 27, 2002·Surgical Oncology·Jiang Liu, Michael R Johnston
Oct 1, 1988·International Journal of Radiation Biology·R J Hodgkiss, M R Stratford
Feb 1, 1990·International Journal of Radiation Oncology, Biology, Physics·M FushikiM Abe
May 1, 1989·International Journal of Radiation Oncology, Biology, Physics·R A KramerV P Montoya

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