The RAF inhibitor paradox revisited.

Cancer Cell
Adrienne D Cox, Channing J Der

Abstract

The success of the RAF protein kinase inhibitor vemurafenib for the treatment of BRAF mutant metastatic melanoma has produced another poster child for the promise of personalized medicine. However, the results of a recent study also reveal unexpected pitfalls in the application of signal transduction-targeted therapies.

Citations

Aug 4, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Alexander H Stegh
Oct 21, 2016·Expert Opinion on Drug Metabolism & Toxicology·Gino A VenaGiuseppe Argenziano
Oct 2, 2019·Molecular Carcinogenesis·Mahamat BabaganaEugene S Kandel
Sep 5, 2020·Current Topics in Medicinal Chemistry·Javeena HussainSrimadhavi Ravi

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