The Ramazzini Institute 13-week study on glyphosate-based herbicides at human-equivalent dose in Sprague Dawley rats: study design and first in-life endpoints evaluation

Environmental Health : a Global Access Science Source
Simona PanzacchiFiorella Belpoggi

Abstract

Glyphosate-based herbicides (GBHs) are the most widely used pesticides worldwide, and glyphosate is the active ingredient of such herbicides, including the formulation known as Roundup. The massive and increasing use of GBHs results in not only the global burden of occupational exposures, but also increased exposure to the general population. The current pilot study represents the first phase of a long-term investigation of GBHs that we are conducting over the next 5 years. In this paper, we present the study design, the first evaluation of in vivo parameters and the determination of glyphosate and its major metabolite aminomethylphosphonic acid (AMPA) in urine. We exposed Sprague-Dawley (SD) rats orally via drinking water to a dose of glyphosate equivalent to the United States Acceptable Daily Intake (US ADI) of 1.75 mg/kg bw/day, defined as the chronic Reference Dose (cRfD) determined by the US EPA, starting from prenatal life, i.e. gestational day (GD) 6 of their mothers. One cohort was continuously dosed until sexual maturity (6-week cohort) and another cohort was continuously dosed until adulthood (13-week cohort). Here we present data on general toxicity and urinary concentrations of glyphosate and its major metabolite AM...Continue Reading

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Citations

Jul 21, 2020·Scientific Reports·Marcella SpinaciGiovanna Galeati
May 31, 2018·Environmental Health : a Global Access Science Source·Philip J Landrigan, Fiorella Belpoggi
Apr 30, 2020·International Journal of Environmental Research and Public Health·Feng ZhangBaoli Zhu
May 9, 2019·Environmental Health : a Global Access Science Source·Melissa J PerryCourtney Irwin
Jan 8, 2019·Environmental Health : a Global Access Science Source·Christina GillezeauEmanuela Taioli
Nov 28, 2020·Risk Analysis : an Official Publication of the Society for Risk Analysis·Daniel G KougiasJennifer Pierce
Oct 20, 2019·The Science of the Total Environment·Seir Antonio Salazar Mercado, Jesús David Quintero Caleño
May 25, 2021·Frontiers in Public Health·Francesca TruzziGiovanni Dinelli
Jul 27, 2021·Frontiers in Endocrinology·María Mercedes MilesiJorgelina Varayoud
Aug 4, 2021·Environmental Health : a Global Access Science Source·Charles BenbrookRobin Mesnage
Jul 9, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Virginia LorenzMaría M Milesi
Nov 28, 2021·International Journal of Molecular Sciences·Marianna MarinoAntonietta Santoro

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