PMID: 9002910Sep 1, 1995Paper

The randomized clinical trial as a powerful means for understanding treatment efficacy

Seminars in Orthodontics
C Phillips, J F Tulloch

Abstract

The comparison of technologies, ie, alternative ways to accomplish the same aim, is inherently difficult. In orthodontics, technology covers a wide spectrum of areas: variations in treatment approach, appliances, wires, diagnostic procedures, and patient management techniques. Clinical trial methodology has been developed to minimize the effect of bias and to provide more objective answers to questions of comparative efficacy and benefits of particular treatments or procedures. The randomized controlled clinical trial (RCT) is now generally considered the strongest research design for the comparison of treatments. This report reviews four issues that should be addressed in planning an RCT: defining the study cohort, selecting the treatment allocation technique, estimating sample size, and performing the trial.

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Citations

Aug 5, 2009·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Marcia MasiLuís Antônio de Arruda Aidar
Feb 6, 2008·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Tony Collett
Nov 16, 2005·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Stella EfstratiadisJoseph Ghafari
Jul 20, 2005·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Lucia H S CevidanesJulio W Vigorito
Jul 20, 2005·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Lucia H S CevidanesJulio W Vigorito
May 21, 2010·The Angle Orthodontist·Tatsuo ShimadaYoshiki Nakamura

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