The randomized clinical trial: bias in analysis

Circulation
G S MayE Passamani

Abstract

The realization that bias in patient selection may influence the results of clinical studies has helped to establish the randomized controlled clinical trial in medical research. However, bias can be equally important at other stages of a trial, especially at the time of analysis. Withdrawing patients from consideration in the analysis because of ineligibility on account of study entry criteria, lack of compliance to the protocol, or data of poor quality may be a source of systematic error. Examples to illustrate the possible consequences are taken from trials in the cardiovascular field. We recommended that reported study results should include outcome data from all subjects randomized in the group to which they were originally assigned.

References

Jun 15, 1976·European Journal of Clinical Pharmacology·G Ahlmark, H Saetre
Feb 9, 1978·The New England Journal of Medicine·UNKNOWN Anturane Reinfarction Trial Research Group
Dec 27, 1979·The New England Journal of Medicine·D L Sackett, M Gent
Jul 8, 1976·The New England Journal of Medicine·D P ByarJ H Ware
Jan 27, 1975·JAMA : the Journal of the American Medical Association
Aug 1, 1967·Journal of Chronic Diseases·D Schwartz, J Lellouch
Jan 21, 1970·Annals of the New York Academy of Sciences·L W Shaw, T C Chalmers
Jan 1, 1968·Journal of Chronic Diseases·M HalperinF Ederer
Jan 31, 1980·The New England Journal of Medicine·UNKNOWN Anturane Reinfarction Trial Research Group
Jun 6, 1980·Science·G B Kolata
Apr 17, 1980·The New England Journal of Medicine·D DeMetsC D Furberg

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Citations

Jan 1, 1997·Journal of Clinical Apheresis·E C Vamvakas
Apr 15, 2000·Journal of Clinical Apheresis·E C Vamvakas
Oct 20, 2001·Science and Engineering Ethics·David L DeMets
Aug 1, 1996·Controlled Clinical Trials·P C Gøtzsche
Mar 1, 1996·Annals of Epidemiology·D Obias-MannoF Goldner
Aug 10, 2000·Vaccine·A D HorneK L Goldenthal
Aug 1, 1997·Addiction·J Moncrieff, D C Drummond
Jul 7, 2001·BMJ : British Medical Journal·P JüniM Egger
Mar 25, 2010·BMJ : British Medical Journal·David MoherDouglas G Altman
Jul 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·K Prasad, T Haines
Apr 25, 2009·BMC Complementary and Alternative Medicine·Tannis JurgensLindsay Lord
Sep 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Nobutaka MasunagaKinji Ishikawa
Dec 5, 2012·The American Journal of Tropical Medicine and Hygiene·Abdou AmzaBruce D Gaynor
Dec 31, 1997·Controlled Clinical Trials·D L DeMets
May 24, 2000·Controlled Clinical Trials·J M Lachin
Jul 1, 1990·Statistics in Medicine·D W Taylor, E G Bosch
Nov 30, 1994·Statistics in Medicine·J M Albert, D L Demets
Jan 1, 1996·The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics·B FreedmanK C Glass
Oct 5, 2011·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Nikolaos PandisTheodore Eliades
Apr 7, 2015·Korean journal of anesthesiology·Sangseok Lee, Hyun Kang
Jun 19, 2007·Pharmacology & Therapeutics·Mark D Lindner
Sep 17, 2011·Journal of Thrombosis and Haemostasis : JTH·J Beyer-Westendorf, H Büller
Dec 17, 2014·Periodontology 2000·Néstor J LópezBenjamín Martinez
Jan 1, 1985·The American Journal of Cardiology·G S Weinstein
Jan 1, 1983·Progress in Cardiovascular Diseases·G S MayB J Geraci
Jan 1, 1982·Progress in Cardiovascular Diseases·G S MayD L DeMets
Jan 1, 1991·Preventive Medicine·D L DeMetsP Carey
Jan 1, 1987·Scandinavian Journal of Caring Sciences·U WaldenströmC Sundelin
Sep 1, 1984·Annals of Emergency Medicine·N S AbramsonK M Detre
Oct 1, 1983·The American Journal of Cardiology·C M Pratt, R Roberts
Mar 30, 2010·Journal of Clinical Epidemiology·David MoherUNKNOWN Consolidated Standards of Reporting Trials Group
Mar 13, 2003·British Journal of Clinical Pharmacology·Jean-Sébastien HulotPhilippe Lechat
Jan 1, 1988·Scandinavian Journal of Rheumatology·G Husby

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