PMID: 9188630Jul 1, 1997Paper

The range and distribution of murine central nervous system cells infected with the gamma(1)34.5- mutant of herpes simplex virus 1

Journal of Virology
N S MarkovitzB Roizman

Abstract

Wild-type herpes simplex virus 1 (HSV-1) multiplies, spreads, and rapidly destroys cells of the murine central nervous system (CNS). In contrast, mutants lacking both copies of the gamma(1)34.5- gene have been shown to be virtually lacking in virulence even after direct inoculation of high-titered virus into the CNS of susceptible mice (J. Chou, E. R. Kern, R. J. Whitley, and B. Roizman, Science 250:1262-1266, 1990). To investigate the host range and distribution of infected cells in the CNS of mice, 4- to 5-week-old mice were inoculated stereotaxically into the caudate/putamen with 3 x 10(5) PFU of the gamma(1)34.5- virus R3616. Four-micrometer-thick sections of mouse brains removed on day 3, 5, or 7 after infection were reacted with a polyclonal antibody directed primarily to structural proteins of the virus and with antibodies specific for neurons, astrocytes, or oligodendrocytes. This report shows the following: (i) most of the tissue damage caused by R3616 was at the site of injection, (ii) the virus spread by retrograde transport from the site of infection to neuronal cell nuclei at distant sites and to ependymal cells by cerebrospinal fluid, (iii) the virus infected neurons, astrocytes, oligodendrocytes, and ependymal ce...Continue Reading

References

Dec 1, 1991·The Journal of Infectious Diseases·Y YamadaY Nishiyama
Jan 1, 1991·Acta Neuropathologica·J R MartinD B Henken
Aug 1, 1990·The Journal of Comparative Neurology·H Kita, S T Kitai
Mar 1, 1989·Neuropathology and Applied Neurobiology·S J WebbM M Esiri
Dec 1, 1985·Journal of the Neurological Sciences·S P NeeleyG R Taylor
Jan 1, 1971·Acta Neuropathologica·K KristenssonJ Sjöstrand
Jun 1, 1972·The Journal of General Virology·T J HillA P Roome
Jul 1, 1974·The Journal of Infectious Diseases·F B KnottsJ G Stevens
Jan 1, 1980·Archives of Virology·E F Lascano, M I Berria
Apr 1, 1982·Journal of the Neurological Sciences·K KristenssonE Lycke
Aug 1, 1983·Journal of the Neurological Sciences·A H Tomlinson, M M Esiri
Mar 1, 1983·The Journal of Comparative Neurology·L L Porter, E L White
Jan 1, 1993·Advances in Experimental Medicine and Biology·S PerlmanG Jacobsen
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·R ChambersR J Whitley
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·B Roizman

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Citations

May 28, 2008·Cellular Microbiology·Anthony Orvedahl, Beth Levine
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·C F BaslerP Palese
Jul 31, 2013·Oncoimmunology·Erika VacchelliLorenzo Galluzzi
Apr 13, 2007·Gene Therapy·A C ShahK A Cassady
Aug 18, 2004·International Journal of Experimental Pathology·Robin Lachmann
Dec 19, 2002·International Reviews of Immunology·Christopher F Basler, Adolfo García-Sastre
May 12, 2010·Journal of Neurochemistry·Eitan OkunMark P Mattson
Sep 15, 2009·Reviews in Medical Virology·Sagar B Kudchodkar, Beth Levine
Dec 24, 2003·International Reviews of Immunology·Ian Mohr
Jan 18, 2006·Reviews in Medical Virology·Adam M SonabendMaciej S Lesniak
Sep 25, 2010·Seminars in Immunopathology·Hee Jin KimJae U Jung
Apr 19, 2018·Advances in Virology·R Eberle, L Jones-Engel
Jun 28, 2003·Journal of Virology·Christopher F BaslerAdolfo García-Sastre
Nov 3, 2006·Journal of Virology·Stephanie A CampbellMatthias Gromeier

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