The rap GTPases regulate B cell morphology, immune-synapse formation, and signaling by particulate B cell receptor ligands

Immunity
K B L LinM R Gold

Abstract

B lymphocytes spread and extend membrane processes when searching for antigens and form immune synapses upon contacting cells that display antigens on their surface. Although these dynamic morphological changes facilitate B cell activation, the signaling pathways underlying these processes are not fully understood. We found that activation of the Rap GTPases was essential for these changes in B cell morphology. Rap activation was important for B cell receptor (BCR)- and lymphocyte-function-associated antigen-1 (LFA-1)-induced spreading, for BCR-induced immune-synapse formation, and for particulate BCR ligands to induce localized F-actin assembly and membrane-process extension. Rap activation and F-actin assembly were also required for optimal BCR signaling in response to particulate antigens but not soluble antigens. Thus by controlling B cell morphology and cytoskeletal organization, Rap might play a key role in the activation of B cells by particulate and cell-associated antigens.

References

Jan 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P G PolakisF McCormick
Mar 22, 2000·The Journal of Cell Biology·K A ReedquistJ L Bos
Jul 27, 2000·Molecular and Cellular Biology·Y OhbaM Matsuda
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·B BoettnerL Van Aelst
Feb 21, 2002·The Journal of Experimental Medicine·Danielle LankarChristian Bonnerot
Feb 6, 2004·The Journal of Cell Biology·Trever G BivonaMark R Philips
Jul 13, 2004·Trends in Cell Biology·Ville O PaavilainenPekka Lappalainen
Oct 8, 2004·Developmental Cell·Esther M LafuenteVassiliki A Boussiotis
Oct 14, 2004·The Journal of Cell Biology·William T ArthurJonathan A Cooper
Mar 23, 2005·Current Opinion in Cell Biology·Johannes L Bos
Jun 21, 2005·Nature Reviews. Immunology·Tatsuo Kinashi
Dec 31, 2005·Molecular and Cellular Biology·Marlena DuchniewiczFried J T Zwartkruis
Feb 4, 2006·The EMBO Journal·Yolanda R Carrasco, Facundo D Batista
Apr 18, 2006·Current Opinion in Immunology·Yolanda R Carrasco, Facundo D Batista
Oct 21, 2006·Nature Immunology·Matthew F Krummel, Ian Macara
Dec 23, 2006·Science·Christopher D C AllenJason G Cyster
Mar 14, 2007·The Journal of Cell Biology·Audrey GérardJohn G Collard
Mar 21, 2007·The Journal of Cell Biology·Taeck J JeonRichard A Firtel

❮ Previous
Next ❯

Citations

Mar 10, 2009·Nature Immunology·Joseph CantorMark H Ginsberg
Oct 12, 2010·Nature Reviews. Immunology·Susan K Pierce, Wanli Liu
Jun 26, 2013·Nature Reviews. Immunology·Maria-Isabel YuseffAna-Maria Lennon-Duménil
Jun 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patricia BarralFacundo D Batista
Dec 4, 2010·The Journal of Biological Chemistry·Ben de WetThomas Harder
Aug 25, 2010·The Journal of Experimental Medicine·Aradhana AwasthiSubramaniam Malarkannan
Nov 16, 2011·Biochemistry. Biokhimii︠a︡·S V Shirshev
Mar 3, 2010·Annual Review of Immunology·Naomi E Harwood, Facundo D Batista
Sep 9, 2010·PloS One·Sebastian KönigsbergerGernot Achatz
Feb 4, 2014·FEBS Letters·Steven MachtalerLinda Matsuuchi
Sep 15, 2010·Immunology Letters·Caren JangLinda Matsuuchi
Dec 30, 2008·Journal of Proteomics·Laura BianchiLuca Bini
May 9, 2009·European Journal of Immunology·Patrick C RaemerCarsten Watzl
Mar 18, 2009·Immunological Reviews·David A Fruman, Georges Bismuth
Oct 15, 2013·Immunological Reviews·Leopoldo Santos-ArgumedoOrestes López-Ortega
Jun 16, 2015·Frontiers in Immunology·Maria-Isabel Yuseff, Ana Maria Lennon-Duménil
May 17, 2008·Immunity·Naomi E Harwood, Facundo D Batista
May 23, 2012·Biochimica Et Biophysica Acta·Linda Matsuuchi, Christian C Naus
Apr 18, 2009·Immunity·Michael L Dustin
Jun 19, 2016·Biochimica Et Biophysica Acta·Natalia AlonsoCarina Shayo
Mar 15, 2018·Physiological Reviews·William G Robichaux, Xiaodong Cheng
Apr 6, 2018·The Journal of Biological Chemistry·Xuefeng ZhangDaniel L Altschuler
May 28, 2013·Oncogene·C E S ComstockK E Knudsen
Apr 16, 2020·Journal of Leukocyte Biology·Yolanda R Carrasco
Jun 15, 2019·The Journal of Cell Biology·Juan José SáezMaría-Isabel Yuseff

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