The Raphe Dopamine System Controls the Expression of Incentive Memory.

Neuron
Rui LinMinmin Luo

Abstract

The brain dopamine (DA) system participates in forming and expressing memory. Despite a well-established role of DA neurons in the ventral tegmental area in memory formation, the exact DA circuits that control memory expression remain unclear. Here, we show that DA neurons in the dorsal raphe nucleus (DRN) and their medulla input control the expression of incentive memory. DRN DA neurons are activated by both rewarding and aversive stimuli in a learning-dependent manner and exhibit elevated activity during memory recall. Disrupting their physiological activity or DA synthesis blocks the expression of natural appetitive and aversive memories as well as drug memories associated with opioids. Moreover, a glutamatergic pathway from the lateral parabrachial nucleus to the DRN selectively regulates the expression of reward memories associated with opioids or foods. Our study reveals a specialized DA subsystem important for memory expression and suggests new targets for interventions against opioid addiction.

References

Jun 27, 1986·Science·L R Squire
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·J L McGaughB Roozendaal
Mar 14, 1997·Science·W SchultzP R Montague
Apr 16, 1999·Nature Neuroscience·R L BucknerS E Petersen
Feb 15, 2001·Brain Research·M El-GhundiS R George
Jun 26, 2001·Science·E J Nestler
Jun 8, 2002·Annual Review of Neuroscience·Mark G Packard, Barbara J Knowlton
Feb 1, 1957·Journal of Neurology, Neurosurgery, and Psychiatry·W B SCOVILLE, B MILNER
Oct 15, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John D WilsonKenny J Simansky
May 21, 2004·Nature Reviews. Neuroscience·Roy A Wise
Aug 2, 2005·The American Journal of Psychiatry·Steven E Hyman
Dec 13, 2005·Nature·Thomas S HnaskoRichard D Palmiter
Jun 17, 2006·Annual Review of Neuroscience·Steven E HymanEric J Nestler
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Blaine N ArmbrusterBryan L Roth
Aug 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Zhong-Qiu ZhaoZhou-Feng Chen
Apr 14, 2009·Nature Methods·Daniel G GibsonHamilton O Smith
Jun 27, 2009·Neuron·Ingrid EhrlichAndreas Lüthi
Aug 19, 2009·Annals of the New York Academy of Sciences·Ivan E de Araujo
Dec 24, 2010·Nature·Kazunari MiyamichiLiqun Luo
Apr 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan-qin LiLin Lu
Jan 27, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Takeshi SuzukiBill J Yates
Mar 16, 2012·Nature·Qi WuRichard D Palmiter
Jun 12, 2012·Neuron·Mitsuko Watabe-UchidaNaoshige Uchida
Jan 25, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·You-Qing CaiZhizhong Z Pan
Sep 14, 2013·Current Biology : CB·Alison R Preston, Howard Eichenbaum
Oct 15, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Roy A Wise, George F Koob
Apr 2, 2014·Frontiers in Behavioral Neuroscience·Yonghui LiGilbert J Kirouac
Jun 21, 2014·Cell·Lisa A GunaydinKarl Deisseroth

❮ Previous
Next ❯

Citations

Nov 1, 2020·International Journal of Molecular Sciences·Marie A LabouesseTommaso Patriarchi
Feb 11, 2021·Proceedings of the National Academy of Sciences of the United States of America·Jun WangHan Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.