PMID: 6109429Jan 1, 1980Paper

The rapid onset of functional tolerance to ethanol--role of different neurotransmitters and synaptosomal membrane lipids

Acta Psychiatrica Scandinavica. Supplementum
J M LittletonS J Grieve

Abstract

The rapid onset of functional tolerance to ethanol was studied in young adult mice of the TO Swiss and C57 Black strains. Drugs known to alter the metabolism of catecholamines and 5-hydroxytryptamine in mouse brain were without effect on the development of tolerance to ethanol. Amino-oxyacetic acid, which potentiates gamma-aminobutyric acid (GABA), slightly inhibited the development of tolerance, whereas the GABA antagonist, picrotoxin, produced a small increase in tolerance. The effects of treatments which altered synaptosomal membrane lipid composition were also investigated. Prolonged treatment of mice with diazacholesterol, an inhibitor of cholesterol synthesis, reduced the cholesterol content of synaptosomal membranes and, while not altering the initial sensitivity of mice to ethanol, prevented the subsequent development of tolerance. In contrast, feeding mice a diet rich in saturated fats throughout their lives reduced the unsaturated fat content of synaptosomal membranes and appeared to reduce the initial sensitivity of mice to ethanol. These results are consistent with our previous hypothesis that a reduction in unsaturation of synaptosomal membrane lipids underlies the rapid onset of ethanol tolerance in mice. They als...Continue Reading

References

Sep 1, 1977·The Journal of Pharmacy and Pharmacology·J M Littleton, G John
Sep 1, 1979·The Journal of Pharmacy and Pharmacology·S J Grieve, J M Littleton
Jun 30, 1975·Biochimica Et Biophysica Acta·R N FaríasR E Trucco
Dec 1, 1979·The British Journal of Addiction to Alcohol and Other Drugs·M Rigby, J M Littleton
Jan 1, 1979·Alcoholism, Clinical and Experimental Research·J M LittletonS J Grieve
Aug 1, 1978·Canadian Journal of Physiology and Pharmacology·J G Sinclair, G F Lo
Nov 16, 1978·Biochimica Et Biophysica Acta·J H ChinD B Goldstein
Dec 7, 1978·Nature·P L HoffmanB Tabakoff
Apr 15, 1977·Experientia·G J LeitchG D Guthrie
Jan 1, 1975·Psychopharmacologia·A E LeBlancR J Gibbins

❮ Previous
Next ❯

Citations

Jun 1, 1996·Annals of Neurology·J A WaterstonS Collins
Aug 18, 2001·Pharmacology, Biochemistry, and Behavior·C L ReedB C Jones
Sep 1, 1995·Visual Neuroscience·D P Hanes, J D Schall
Mar 24, 1997·Neuroreport·E P O'SullivanC Kennard
Aug 24, 2012·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Owen B White, Joanne Fielding
Oct 1, 1979·The Journal of Pharmacy and Pharmacology·S J Grieve, J M Littleton
Aug 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·Y W ChanP A Feary
Dec 1, 1989·Alcoholism, Clinical and Experimental Research·J T KerrD W Crabb
Nov 11, 2008·Pharmacology, Biochemistry, and Behavior·Daniel RialGina Struffaldi Morato
Jan 1, 1982·Alcoholism, Clinical and Experimental Research·R Bühler, J P von Wartburg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.