PMID: 9437788Jan 23, 1998Paper

The rat androgen-binding protein (ABP/SHBG) gene contains triplet repeats similar to unstable triplets: evidence that the ABP/SHBG and the fragile X-related 2 genes overlap

Steroids
D R Joseph

Abstract

The rat androgen-binding protein/sex hormone-binding globulin (ABP/SHBG) gene is regulated by promoters P1 and PA. P1 regulates the mRNA encoding secreted ABP/SHBG, whereas PA regulates an alternate mRNA which encodes a modified protein that is targeted to the nucleus. Promoter PA is GC rich, consisting of 70-80% GC residues. During routine BLAST sequence analysis it was discovered that this GC-rich region is highly related to the human fragile X-related protein 2 (FXR-2) 5'-untranslated RNA sequence. Furthermore, the nucleotide coding sequence of the initial 14 FXR-2 amino acid residues was identical in the ABP/SHBG gene. The 5'-untranslated FXR-2 sequence contains triplet (CGG) repeats, which are also present in the rat ABP/SHBG gene. The meiotic instability of CGG repeats in the human fragile X (FMR1) gene causes the fragile X mental retardation syndrome. The data presented here suggest that the ABP/SHBG and FXR-2 genes overlap with each gene transcribed in the opposite direction. In support of this structure, the human ABP/SHBG and the FXR-2 genes map to the same site on chromosome 17. Thus, the ABP/SHBG gene contains triplet repeats in the alternate promoter PA. It will be of particular interest to determine if triplet ins...Continue Reading

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M VellardB Perbal
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Mar 1, 1989·Trends in Genetics : TIG·J H Nadeau

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Citations

Feb 12, 2002·Neuroscience and Biobehavioral Reviews·Jack D Caldwell
Feb 1, 2005·Computational Biology and Chemistry·Izabela MakalowskaWojciech Makalowski
May 21, 1999·Biochemical and Biophysical Research Communications·Z LiuR A Dunham
Feb 9, 2000·Genomics·P CousinP Shaw
Aug 5, 2006·The Biochemical Journal·Lata Mahishi, Karen Usdin
Jun 3, 1999·Genetics·S ShintaniJ Klein

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