The rat caudal nerves: a model for experimental neuropathies

Journal of the Peripheral Nervous System : JPNS
Herbert H SchaumburgJ C Arezzo

Abstract

This study provides a detailed investigation of the anatomy of the rat caudal nerve along its entire length, as well as correlated nerve conduction measures in both large and small diameter axons. It determines that rodent caudal nerves provide a simple, sensitive experimental model for evaluation of the pathophysiology of degeneration, recovery, and prevention of length-dependent distal axonopathy. After first defining the normal anatomy and electrophysiology of the rat caudal nerves, acrylamide monomer, a reliable axonal toxin, was administered at different doses for escalating time periods. Serial electrophysiological recordings were obtained, during intoxication, from multiple sites along caudal and distal sciatic nerves. Multiple sections of the caudal and sciatic nerves were examined with light and electron microscopy. The normal distribution of conduction velocities was determined and acrylamide-induced time- and dose-related slowing of velocities at the vulnerable ultraterminal region was documented. Degenerative morphological changes in the distal regions of the caudal nerves appeared well before changes in the distal sciatic nerves. Our study has shown that (1) rat caudal nerves have a complex neural structure that va...Continue Reading

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Citations

Apr 13, 2013·Physiology Journal·Elena G Zotova, Joseph C Arezzo
Oct 7, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Paweł ReichertAneta Bocheńska
Oct 28, 2014·Muscle & Nerve·Samuel J MackenzieBlair Calancie
Feb 16, 2011·Journal of Neuroscience Methods·Ayhan KilicPeter Tang
Jun 7, 2016·Journal of Pharmacological and Toxicological Methods·Simon AuthierMichael J Curtis
Jul 6, 2014·Polish Journal of Veterinary Sciences·P ReichertA Bocheńska
Jul 17, 2020·The International Journal of Neuroscience·Kamil SavaşNazmi Yaraş
Jul 28, 2019·Toxicologic Pathology·Mark T Butt

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