The rat corticospinal system is functionally and anatomically segregated

Brain Structure & Function
Rafael Olivares-MorenoGerardo Rojas-Piloni

Abstract

The descending corticospinal (CS) projection has been considered a key element for motor control, which results from direct and indirect modulation of spinal cord pre-motor interneurons in the intermediate gray matter of the spinal cord, which, in turn, influences motoneurons in the ventral horn. The CS tract (CST) is also involved in a selective and complex modulation of sensory information in the dorsal horn. However, little is known about the spinal network engaged by the CST and the organization of CS projections that may encode different cortical outputs to the spinal cord. This study addresses the issue of whether the CS system exerts parallel control on different spinal networks, which together participate in sensorimotor integration. Here, we show that in the adult rat, two different and partially intermingled CS neurons in the sensorimotor cortex activate, with different time latencies, distinct spinal cord neurons located in the dorsal horn and intermediate zone of the same segment. The fact that different populations of CS neurons project in a segregated manner suggests that CST is composed of subsystems controlling different spinal cord circuits that modulate motor outputs and sensory inputs in a coordinated manner.

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Citations

Mar 24, 2020·Brain : a Journal of Neurology·C Sahara KhademullahMelanie A Woodin
Sep 25, 2019·BMC Neuroscience·Rafael Olivares-MorenoGerardo Rojas-Piloni
May 3, 2018·Cerebral Cortex·Olivier D LaflammeFrédéric Bretzner
Jan 20, 2021·Neuroscience·Mohammed Gamal-EltrabilyMiguel Condés-Lara
Jun 29, 2021·Frontiers in Neuroscience·Rafael Olivares-MorenoGerardo Rojas-Piloni
Sep 10, 2021·ELife·Yunuen Moreno-LopezMatilde Cordero-Erausquin

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