The rat epididymal fat pad as an implantation site for the study of microcapsule biocompatibility: validation of the method

Journal of Biomedical Materials Research
J F PariseauJ P Hallé

Abstract

The study of microcapsule biocompatibility is hindered by their uneven distribution and low recovery when implanted into the peritoneum. We evaluated the use of the rat epididymal fat pad as a microcapsule implantation site for biocompatibility studies. The recovery rate of microcapsules containing 85Sr-labeled microspheres was 99.6 +/- 0.75%. Microcapsules made from the same batch of nonpurified alginate, were injected into both fat pads of male Lewis rats (n = 18) and retrieved 14 days later. A semiquantitative fibrosis score scaled from 0 to 3.0 showed that the pericapsular reaction was uniform throughout a fat pad, and that the results of the two fat pads were equivalent because the null hypothesis of inequivalence was rejected (P < .001). Thus, this method can be used to compare the biocompatibility of microcapsule of differing compositions.

References

Jul 23, 1992·The New England Journal of Medicine·K L PyzdrowskiR P Robertson
Feb 1, 1992·Transplantation·C RicordiD H Mintz
Apr 1, 1991·Journal of Microencapsulation·H A ClaytonR F James
May 1, 1986·Journal of Clinical Periodontology·N W Chilton, J L Fleiss
Dec 1, 1982·Controlled Clinical Trials·W C Blackwelder
Oct 23, 1964·Science·T M CHANG

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Citations

Aug 16, 2000·Advanced Drug Delivery Reviews·H UludagP A Tresco
Jan 25, 2005·Biomaterials·Robert RobitailleJean-Pierre Hallé
May 9, 2006·Journal of Biomedical Materials Research. Part a·Shinji SakaiKoei Kawakami
Jun 15, 1997·Journal of Biomedical Materials Research·S K WilliamsL B Kleinert

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