PMID: 8611621Apr 10, 1996Paper

The rat FGF-5 mRNA variant generated by alternative splicing encodes a novel truncated form of FGF-5

Biochimica Et Biophysica Acta
Y HattoriN Itoh

Abstract

We isolated rat FGF-5 cDNA and its variant from the embryo. The FGF-5 cDNA encodes a protein of 266 amino acid residues. The variant cDNA encodes a protein of 121 amino acid residues, the N-terminal 117-amino acid sequence of which is identical to that of FGF-5. Thus the variant cDNA encodes a novel truncated form of FGF-5. The rat FGF-5 gene consists of three exons (exons 1-3). The variant cDNA lacks the nucleotide sequence of exon 2, indicating that the variant mRNA is generated by alternative splicing. The variant mRNA as well as the FGF-5 mRNA was detected in the embryo and adult brain. This is the first description of the mRNA for a truncated form of FGF within the FGF family.

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Citations

Jul 1, 1997·Brain Research. Molecular Brain Research·Y HattoriN Itoh
Jul 7, 2001·Neuroscience·A B McGeachieUNKNOWN Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
Sep 15, 2009·BMC Evolutionary Biology·Alfred L RocaAlex D Greenwood
Jan 10, 2002·Biochemical and Biophysical Research Communications·Yutaka OtaToru Imamura
Jan 1, 2014·Genetics, Selection, Evolution : GSE·Romain LegrandMarie Abitbol
Feb 26, 2000·The Journal of Investigative Dermatology·S SuzukiT Imamura
Jun 21, 2017·The FEBS Journal·Wen-Rong LiMing-Jun Liu

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