PMID: 9448288Mar 14, 1998Paper

The rat gene homologous to the human gene 9-27 is involved in the development of the mammary gland

Proceedings of the National Academy of Sciences of the United States of America
I ZucchiR Dulbecco

Abstract

We have developed a model system for studying differentiation in the mammary gland, by using two clonal cultures deriving from a rat breast adenocarcinoma. They differ in the ability to form domes, structures the significance of which is unknown. By using the subtractive cDNA library approach, we isolated a cDNA that is highly expressed in the dome-forming cells, and identical to the rat8 gene and highly homologous to the human 9-27 gene. Antisense treatment of the dome-forming cells specifically and reproducibly abolishes dome formation, while forced expression of the gene in non-dome-forming cells causes morphological changes suggestive of "flat" domes. In situ hybridization on rat tissues shows that the gene is expressed in epithelia, especially in those forming tubular structures, suggesting a relatedness between these structures and domes. Cytokeratin 8 and E cadherin are strongly expressed in the domes but not outside them, suggesting that the rat8 gene triggers the cells to express molecules that tighten the lateral connections between the cells; the process is likely to parallel that occurring during the differentiation of the mammary gland.

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Citations

Sep 15, 2010·Journal of Bone and Mineral Metabolism·Nobutaka HanagataTakashi Minowa
Oct 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·I ZucchiR Dulbecco
Feb 26, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Pia Møller Martensen, Just Justesen
Dec 21, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Fredy SiegristUlrich Certa
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·I ZucchiR Dulbecco
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·I ZucchiR Dulbecco
May 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·I ZucchiR Dulbecco
Feb 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·I ZucchiR Dulbecco
Jun 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·I ZucchiR Dulbecco
Sep 17, 2009·Reproduction in Domestic Animals = Zuchthygiene·C CocolaI Zucchi
Mar 7, 2006·Biochemical and Biophysical Research Communications·Rama S KotaChilakamarti V Ramana
Mar 3, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jing CuiJoan Burnside
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Irene CattaneoAndrea Remuzzi

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