The rat melanin-concentrating hormone messenger ribonucleic acid encodes multiple putative neuropeptides coexpressed in the dorsolateral hypothalamus.

Endocrinology
J L NahonW Vale

Abstract

The melanin-concentrating hormone (MCH) is a cyclic neuropeptide, first isolated from salmon pituitary glands, which regulates melanin dispersion in the skin and perhaps the activity of the pituitary-adrenal axis in teleost fish. We have recently purified and characterized rat MCH (rMCH) and report here the cloning and sequencing of specific MCH cDNA isolated from a rat hypothalamic library. The sequence of rMCH found by DNA sequencing confirms the sequence deduced from the purified peptide. rMCH is located at the C-terminus of a protein precursor of 165 amino acid residues. Comparison of the amino acid sequence of prepro-MCH and that of the Aplysia peptide-A prohormone suggests that these proteins as well as other precursors may be evolutionarily related. Besides rMCH, two putative neuropeptides, termed NGE and NEI, might be generated from the same precursor. The rMCH precursor shared sequence identities with human GH-releasing factor and mammalian CRF in the regions encoding NGE and NEI. By immunohistochemical studies we have established that the amidated C-terminus of NEI is recognized by some alpha MSH and rat CRF antisera and that the C-terminal portion of NGE is responsible for the cross-reactivity revealed with one hGRF-...Continue Reading

Citations

Feb 10, 1998·The Journal of Comparative Neurology·M VallarinoH Vaudry
Apr 1, 1992·Journal of Neuroscience Research·J QuinnR W Baughman
Jul 1, 1993·Fish Physiology and Biochemistry·D GröneveldS E Wendelaar Bonga
Jun 1, 1993·Brain Research. Molecular Brain Research·C BretonJ L Nahon
Jul 20, 2002·Biochemical and Biophysical Research Communications·Valérie AudinotJean A Boutin
Sep 5, 1998·Brain Research·C L MillerR C Thompson
Dec 22, 1999·Physiology & Behavior·M E Monzón, S R De Barioglio
Jun 19, 2001·Brain Research. Molecular Brain Research·V SergeyevT Hökfelt
Jan 22, 2003·Peptides·J J G HillebrandR A H Adan
Sep 21, 2000·Trends in Endocrinology and Metabolism : TEM·Y SaitoO Civelli
Jun 27, 2003·Trends in Endocrinology and Metabolism : TEM·Pavlos Pissios, Eleftheria Maratos-Flier
Jun 12, 2002·Canadian Journal of Physiology and Pharmacology·Jean A BoutinJean-Luc Fauchère
May 18, 2001·Biochemical and Biophysical Research Communications·M MoriM Fujino
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·S AnK Dai
Jul 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hilary SandigDavid J Cousins
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Donald J MarshSu Qian
Aug 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Peter BergmanTomas Hökfelt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.