PMID: 2107330Feb 1, 1990Paper

The rat P450 IID subfamily: complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site

Journal of Molecular Evolution
E MatsunagaF J Gonzalez

Abstract

Four genes in the P450 IID gene subfamily were isolated from Sprague-Dawley rat lambda EMBL 3 and Charon 4A genomic libraries and completely sequenced. Their transcription start sites were determined by primer extension analysis. The four genes designated IID2, IID3, IID4, and IID5 span 4036, 4371, 4678, and 4567 bp, respectively, and are closely linked head to tail on a 60-kb segment of DNA. All IID genes contained nine exons, and interestingly, the IID2, IID3, and IID4 genes possessed an atypical GC5' splice junction in intron 2. All four genes are transcribed, however, IID4 mRNA is produced at a level of less than one-tenth of those of IID2, IID3, and IID5. The exonic regions of these genes displayed from 79 to 84% sequence similarties. Several regions of extremely high nucleotide similarity were found within the introns, exons, and in the flanking regions of the four genes. These localized areas of high nucleotide similarities are the result of former gene conversion events. Of interest was the finding that the most highly similar region of all IID genes that was maintained by gene conversion covers portions of the eighth and ninth exons and the eighth intron. The ninth exon codes for a region of the P450 protein that is we...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Sep 1, 1976·Nucleic Acids Research·N Blin, D W Stafford
Apr 1, 1989·Trends in Genetics : TIG·G A Dover
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Y HigashiY Fujii-Kuriyama
Apr 1, 1987·Journal of Biochemistry·K MorohashiY Fujii-Kuriyama
Jan 1, 1987·Journal of Molecular Evolution·G A Dover
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W R Pearson, D J Lipman
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M AmorP C White
Jan 1, 1987·Annual Review of Biochemistry·D W Nebert, F J Gonzalez
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M Atchison, M Adesnik
Feb 1, 1987·DNA·D W NebertW Levin
Feb 15, 1985·The Biochemical Journal·K P Ellis, K E Davies
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M Church, W Gilbert

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Citations

Nov 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M LabudaF H Glorieux
Oct 14, 2000·Archives of Biochemistry and Biophysics·N BlumeJ Fishman
Jan 6, 1995·Molecular & General Genetics : MGG·M FreyA Gierl
Jun 1, 1991·Journal of Molecular Evolution·D R WinesR J MacDonald
May 24, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·I P KanaevaA I Archakov
Jun 24, 2003·Biochimica Et Biophysica Acta·Dai MizunoYoshihiko Funae
Jan 1, 1996·Biochimie·E F KolesanovaA I Archakov
May 23, 1998·Biochimica Et Biophysica Acta·T HiroiY Funae
Jan 29, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A I ArchakovV G Zgoda
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·C F HungM A Schuler
Jun 1, 1994·DNA and Cell Biology·M V Frolov, V E Alatortsev
Jan 1, 1995·DNA and Cell Biology·M B Cohen, R Feyereisen
May 25, 1991·Nucleic Acids Research
Feb 17, 1999·Annual Review of Entomology·R Feyereisen
Jun 30, 2000·Biochemical and Biophysical Research Communications·Y D IvanovA I Archakov
Apr 25, 2000·Archives of Biochemistry and Biophysics·V V ShumyantsevaA I Archakov
Jan 1, 1995·Drug Metabolism Reviews·V Ravindranath, M R Boyd
Aug 3, 2000·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S MiksysR F Tyndale
Nov 1, 1995·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A NakamuraS Fujita
Jul 6, 2010·Biochimica Et Biophysica Acta·R Feyereisen
Sep 18, 2002·Biochemical Pharmacology·Hiroyuki HichiyaShizuo Narimatsu
Dec 25, 2004·Drug Metabolism and Pharmacokinetics·Yoshihiko FunaeToyoko Hiroi
Dec 1, 2010·European Journal of Pharmacology·Anna HaduchWładysława A Daniel
May 8, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Noriaki SakaiMayumi Ishizuka
Oct 18, 2003·Endocrinology·Wataru KishimotoYoshihiko Funae
Jun 18, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·David M StresserCharles L Crespi
Dec 24, 2002·The Journal of Pharmacy and Pharmacology·Władysława A DanielJ Wójcikowski

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