The rat ventral island flap: a comparison of the effects of reduction in arterial inflow and venous outflow

Plastic and Reconstructive Surgery
A P RobertsT A Cook

Abstract

The relative importance of reduced arterial inflow versus reduced venous outflow in determining flap necrosis remains undefined, even though this is critically important in understanding the effects of pharmacologic agents on flap survival. By means of a rat bipedicled ventral island flap, the amount of random flap necrosis was examined in four experimental groups: (1) unilateral arteriovenous ligation (n = 19), (2) unilateral vein ligation (n = 20), (3) unilateral artery ligation (n = 20), and (4) alternate side vein and artery ligation (n = 18). No necrosis occurred on the side of the vein ligation in groups 2 and 4, indicating that independently reducing venous outflow does not cause flap necrosis. A predictable necrosis occurred ipsilateral to artery ligation in groups 1 (37.63 +/- 17.34 percent), 3 (32.74 +/- 17.32 percent), and 4 (15.70 +/- 9.86 percent). These data indicate that the rat ventral island flap is more sensitive to a decrease in arterial inflow than to a decrease in venous outflow. This model may therefore be useful in clarifying the effect and determining the mechanism of action of pharmacologic agents that alter flap survival.

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Citations

Jun 12, 1998·Plastic and Reconstructive Surgery·M AkyürekA Keçik
Jan 7, 2004·Plastic and Reconstructive Surgery·Hak ChangHideo Nakajima
May 24, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Yusuke YamamotoMotohiro Nozaki
Oct 25, 2017·Plastic and Reconstructive Surgery. Global Open·Diogo CasalJoão Goyri-O'Neill
Aug 5, 2005·Plastic and Reconstructive Surgery·Geoffrey G Hallock, David C Rice
Apr 7, 2007·Plastic and Reconstructive Surgery·Léo Francisco DoncattoPedro Djacir Escobar Martins
Feb 28, 2008·Plastic and Reconstructive Surgery·Shimpei MiyamotoKiyonori Harii
Oct 2, 2003·Annals of Plastic Surgery·Kazufumi SanoDavid C Rice

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