PMID: 2105064Jan 1, 1990Paper

The rate of CSF formation, resistance to reabsorption of CSF, and aperiodic analysis of the EEG following administration of flumazenil to dogs

Anesthesiology
A A Artru

Abstract

The effects of flumazenil, a benzodiazepine antagonist, on the rate of cerebrospinal fluid (CSF) formation (Vf), resistance to reabsorption of CSF (Ra) and the electroencephalogram (EEG) was determined in 12 dogs anesthetized with halothane (0.4%, end-expired) and nitrous oxide (66%, inspired) in oxygen. In six dogs the responses to flumazenil were measured during administration of midazolam (1.6 mg/kg followed by 1.25 mg.kg-1.h-1, intravenously) given along with inhalational anesthesia, whereas in the other six dogs the responses to flumazenil were measured during inhalational anesthesia without midazolam. Vf and Ra were determined using ventriculocisternal perfusion, and EEG activity was evaluated using aperiodic analysis. Flumazenil, 0.0025 and 0.16 mg/kg, was administered both when CSF pressure was normal and when CSF pressure was increased to 36-38 cmH2O by continuous infusion of mock CSF. Flumazenil produced no statistically significant change in Vf. Flumazenil did produce inconsistent and relatively small changes in Ra. Quantitative aperiodic analysis indicated changes in EEG activity only when the larger dose of flumazenil was given to dogs receiving midazolam. At normal CSF pressure the changes were consistent and were...Continue Reading

Citations

Apr 1, 1993·Electroencephalography and Clinical Neurophysiology·T DierksK Maurer
Mar 19, 2019·Anesthesia and Analgesia·Helene BenvenisteNora D Volkow

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